The invention discloses a practical method for preparing high-thixotropy surface treatment nano calcium carbonate, which comprises the following steps: firstly, calcining and digesting preferable limestone, and then controlling carbonization of the limestone in a special reactor to obtain nano calcium carbonate primary slurry; secondly, carrying out surface treatment on the nano calcium carbonate according to practical and special control technology; and finally dehydrating, drying, crushing and grading the coated slurry. The shape of the obtained calcium carbonate is cubic, the particle diameter is 50 to 100 nanometers, and the specific surface area is 20 to 40 m/g. The obtained powder has good dispersion effect and thixotropy, is suitable for occasions needing high thixotropy, such as high-performance silicone adhesive, epoxy adhesive, polysulfide adhesive, polyurethane adhesive, automotive primary coat, floor coating and the like, and has wide market prospect. The method has simple raw materials and process requirement, stabalizes the production and reduces the cost.