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Method, program, and apparatus utilizing fluorescence fingerprint analysis for quantifying tsnas in processed raw material

A fluorescence, raw material technology, applied in the field of TSNAs quantification, can solve the problem of labor and time in pretreatment

Pending Publication Date: 2021-04-16
JAPAN TOBACCO INC
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Problems solved by technology

However, in this method, labor and time are required for sample pretreatment and measurement

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  • Method, program, and apparatus utilizing fluorescence fingerprint analysis for quantifying tsnas in processed raw material
  • Method, program, and apparatus utilizing fluorescence fingerprint analysis for quantifying tsnas in processed raw material
  • Method, program, and apparatus utilizing fluorescence fingerprint analysis for quantifying tsnas in processed raw material

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Embodiment approach

[0167] The inventors of the present invention have conducted detailed research and found that, in the fluorescence fingerprint information acquisition process in the above-mentioned embodiment, by measuring fluorescence through a filter for reducing the intensity of light in a specific wavelength range, further improvement is expected. Improve forecast accuracy. Hereinafter, this will be described in detail.

[0168] Figure 9 Yes means that for containing and Figure 6 An example of fluorescent fingerprints obtained by this method for the same TSNAs reagent sample. In addition, the sample was prepared by mixing the four TSNAs reagents with the ethanol solution at approximately the same ratio as that of Burley tobacco, and the total of the four TSNAs contained in the sample was 1.28 μg / g.

[0169] Figure 9 The area marked with "A"" in the oval box ("Area A") is the area where the fluorescent fingerprint information of the four TSNAs was confirmed in the specimen, which is...

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Abstract

The invention is to quickly and accurately quantify four types of TSNAs contained in a tobacco raw material by using fluorescence fingerprint information. A tobacco raw material containing known quantities of four types of TSNAs is prepared (S01), and fluorescence fingerprint information thereof is acquired (S02). The fluorescence fingerprint information is pre-processed, as needed (S03), and an estimation model (calibration curve) for estimating the total quantity of the four types of TSNAs from the fluorescence fingerprint information is created (S04). After verifying the calibration curve (S05), the total quantity of the four types of TSNAs contained in an unknown tobacco raw material is estimated by applying the calibration curve to the unknown tobacco raw material (S06). On the basis of the estimated value of the total quantity of the four types of TSNAs and the known abundance ratios of the individual TSNAs, the contained quantities of the four types of TSNAs are estimated (S07).

Description

technical field [0001] The present invention relates to a quantitative method, program and device for TSNAs in treated raw materials using fluorescence fingerprint analysis, and in particular to a quantitative method, program and device applicable to the quantification of trace components in TSNAs. [0002] In addition, TSNAs refer to tobacco-specific nitrosamines (Tobacco-specific nitrosamines), and as typical TSNAs, NNN (N'-nitrosonornicotine), NNK (4-(methylnitrosoamino)- 1-(3-pyridyl)-1-butanone), NAT (N'-nitrosoanatabine), and NAB (N'-nitrosoanabatin). Background technique [0003] A general method for measuring components in a sample is to extract various components in the sample with an extract and quantify them using high performance liquid chromatography (HPLC-MS / MS). However, this method requires labor and time for sample pretreatment and measurement. [0004] In order to analyze and quantify the components in the sample, analysis using near-infrared (Near-Infrar...

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Application Information

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IPC IPC(8): G01N21/64
CPCG01N2201/1293G01J3/4406G01N2021/6419G01N2021/6421G01N21/6486A24B15/10G01N21/278G01N21/84G01N2021/8466
Inventor 内藤启贵小池巧
Owner JAPAN TOBACCO INC
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