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Application of group of immune-related molecular markers identified based on TCGA database in prognosis prediction of esophageal cancer

A molecular marker and immune-related technology, applied in the prognosis prediction of esophageal cancer, in the field of immune-related molecular markers, can solve the problems of less research on the role of immune-related genes, and the incomplete elucidation of the prognostic value of immune-related genes. Improving the efficiency of immunotherapy and promoting the effect of development

Inactive Publication Date: 2021-04-20
徐同鹏
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

However, the prognostic value of immune-related genes in the two pathological subtypes of esophageal cancer has not been fully elucidated
Less research on the role of immune-related genes in the survival and prognosis of different subtypes of esophageal cancer

Method used

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  • Application of group of immune-related molecular markers identified based on TCGA database in prognosis prediction of esophageal cancer
  • Application of group of immune-related molecular markers identified based on TCGA database in prognosis prediction of esophageal cancer
  • Application of group of immune-related molecular markers identified based on TCGA database in prognosis prediction of esophageal cancer

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Embodiment Construction

[0032] The present invention will be further explained below in conjunction with the accompanying drawings and specific embodiments. It should be understood that the following specific embodiments are only used to illustrate the present invention and are not intended to limit the scope of the present invention.

[0033] Methods and Materials

[0034] Data collection and processing

[0035] The TCGA database (https: / / cancergenome.nih.gov / ) was used to obtain transcriptome data, clinical data, and follow-up data of immune-related genes in patients with esophageal cancer. In the ImmPort data portal, a list of immune-related genes was exported.

[0036] Screening for differentially expressed genes

[0037] The Edger algorithm was used to find differentially expressed genes, and |logFC|>1 and FDR<0.05 were used as screening criteria.

[0038] Identification of differentially expressed immune-related genes

[0039] The above differentially expressed genes were hybridized with immun...

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Abstract

The invention discloses application of a group of immune-related molecular markers in tissues identified based on a TCGA database in esophageal cancer prognosis. The application specifically comprises the following steps: establishing an immune gene prognosis model related to esophageal cancer prognosis; the method for establishing the model comprises the following steps: step 1, collecting and processing data; step 2, screening differentially expressed genes; and step 3, identifying differentially expressed immune related genes; step 4, performing transcription factor analysis and construction of a transcription factor immune differential expression gene regulation and control network; step 5, performing survival analysis; and step 6, establishing a prognosis risk index evaluation model based on esophageal cancer immune related genes.

Description

technical field [0001] The invention relates to the field of tumor molecular biology, in particular to the application of a group of immune-related molecular markers identified based on the TCGA database in the prognosis prediction of esophageal cancer. Background technique [0002] Globally, esophageal cancer is the seventh most common cancer and the sixth leading cause of cancer death. The 5-year survival rate of patients with esophageal cancer is less than 20%, and the mortality rate is very high, seriously affecting human health. In 2017, the global incidence and death toll of esophageal cancer were 473,000 and 436,000, respectively. In 2020, it is estimated that about 18,440 people in the United States will be diagnosed with esophageal cancer, and 16,170 people will die of esophageal cancer. The treatment of esophageal cancer mainly focuses on preoperative chemotherapy or postoperative radiotherapy and chemotherapy. However, 50% of patients are dissatisfied with the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B40/00G16B20/00C12Q1/6886
Inventor 徐同鹏张皓朱玲
Owner 徐同鹏
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