Preparation method of Chanlong asthma-relieving soft capsule

A soft capsule and toad dragon technology, which is applied in the directions of capsule delivery, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. Soft capsule disintegration delay and other problems, to achieve the effect of improving bioavailability, good bad smell, and improving curative effect

Inactive Publication Date: 2021-04-30
锦州福寿堂医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(1) Traditional Chinese medicine soft capsules often have the disadvantages of inaccurate loading, uneven shape of contents, and easy layering
(2) Traditional Chinese medicine soft capsules mainly use gelatin as the capsule material. During storage, gelatin is prone to cross-linking reactions, causing deformation of the collagen micelles in the gelatin structure, preventing water molecules from entering the interior of the gelatin, making it difficult for the soft capsule to disintegrate. Slow disintegration of soft capsules

Method used

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  • Preparation method of Chanlong asthma-relieving soft capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Weigh raw material drug component A: earthworm 250kg, red ginseng 10kg, astragalus 100kg, ephedra 250kg, schisandra chinensis 100kg, psoralen 75kg, epimedium 150kg, cassia twig 75kg, angelica 75kg, white peony root 100kg, tangerine peel 50kg, Qing Pinellia 75kg, almond 100kg, roasted licorice 75kg, bellflower 50kg and perilla leaves 150kg;

[0033] Wash the earthworm and red ginseng, cut the earthworm, slice the red ginseng, mix with astragalus, ephedra, schisandra, psoralen, epimedium, cassia twig, angelica, white peony root, tangerine peel, pinellia chinensis, almond , Radix Glycyrrhiza, Platycodon grandiflorum and perilla leaf raw materials add water accounting for 8 times the total mass of raw drug component A, extract three times, extraction temperature is 100 ° C, each time for 2 hours, combine decoctions, filter, and concentrate the filtrate to obtain Chinese medicine extract A;

[0034] (2) Take 5kg of toad, break it into pieces, mix it with 50kg of dried g...

Embodiment 2

[0048] (1) Weigh raw material drug component A: earthworm 250kg, red ginseng 10kg, astragalus 100kg, ephedra 250kg, schisandra chinensis 100kg, psoralen 75kg, epimedium 150kg, cassia twig 75kg, angelica 75kg, white peony root 100kg, tangerine peel 50kg, Qing Pinellia 75kg, almond 100kg, roasted licorice 75kg, bellflower 50kg and perilla leaves 150kg;

[0049] Wash the earthworm and red ginseng, cut the earthworm, slice the red ginseng, mix with astragalus, ephedra, schisandra, psoralen, epimedium, cassia twig, angelica, white peony root, tangerine peel, pinellia chinensis, almond , Radix Glycyrrhiza, Platycodon grandiflorum and perilla leaf raw materials add water accounting for 8 times the total mass of raw drug component A, extract three times, extraction temperature is 100 ° C, each time for 2 hours, combine decoctions, filter, and concentrate the filtrate to obtain Chinese medicine extract A;

[0050] (2) Take 5kg of toad, break it into pieces, mix it with 50kg of dried g...

Embodiment 3

[0064] (1) Weigh raw material drug component A: earthworm 250kg, red ginseng 10kg, astragalus 100kg, ephedra 250kg, schisandra chinensis 100kg, psoralen 75kg, epimedium 150kg, cassia twig 75kg, angelica 75kg, white peony root 100kg, tangerine peel 50kg, Qing Pinellia 75kg, almond 100kg, roasted licorice 75kg, bellflower 50kg and perilla leaves 150kg;

[0065] Wash the earthworm and red ginseng, cut the earthworm, slice the red ginseng, mix with astragalus, ephedra, schisandra, psoralen, epimedium, cassia twig, angelica, white peony root, tangerine peel, pinellia chinensis, almond , Radix Glycyrrhiza, Platycodon grandiflorum and perilla leaf raw materials add water accounting for 8 times the total mass of raw drug component A, extract three times, extraction temperature is 100 ° C, each time for 2 hours, combine decoctions, filter, and concentrate the filtrate to obtain Chinese medicine extract A;

[0066] (2) Take 5kg of toad, break it into pieces, mix it with 50kg of dried g...

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Abstract

The invention provides a preparation method of a Chanlong asthma-relieving soft capsule. The preparation method comprises the following steps: mixing earthworm, red ginseng, astragalus membranaceus, ephedra, schisandra chinensis, fructus psoraleae, herba epimedii, cassia twig, angelica sinensis, radix paeoniae alba, pericarpium citri reticulatae, rhizoma pinelliae preparata, almond, radix glycyrrhizae preparata, platycodon grandiflorum and perilla leaf; carrying out water extraction and concentration on the leaves to obtain a traditional Chinese medicine extract A; taking toads, breaking the toads, performing water extraction and alcohol precipitation on the toads, dried ginger and pig bile, and performing concentration to obtain a traditional Chinese medicine extract B; mixing and drying the traditional Chinese medicine extract A and the traditional Chinese medicine extract B, and adding fatty glyceride and soybean oil to obtain a capsule filling liquid; sequentially adding water and glycerin into a glue melting tank, and adding sorbitol, titanium dioxide, iron oxide yellow and gelatin to prepare a glue solution; and pressing the capsule filling liquid and the glue solution into capsules in a soft capsule machine, shaping, washing the capsules, and drying to obtain the toad dragon asthma-relieving soft capsules. According to the invention, the preparation method is simple, the cost is low, oil leakage of the soft capsule is avoided, the content can be kept stable for a long time, and the content is good in uniformity and disintegration effect.

Description

technical field [0001] The invention relates to a preparation method of Chanlong Dingchuan Soft Capsule. Background technique [0002] Chanlong Dingchuan Mixture is based on Xiaoqinglong Decoction in Zhang Zhongjing's "Treatise on Febrile Diseases". After years of clinical practice, Chanlong Dingchuan Mixture is a very effective Chinese patent medicine for chronic asthma. It has the effects of dispelling cold and resolving phlegm, nourishing the lung, invigorating the spleen, nourishing the kidney, relieving cough and relieving asthma; it is used for chronic bronchitis, chronic bronchitis combined with emphysema, chronic bronchitis combined with pulmonary heart disease, Bronchial asthma; can quickly relieve cough, reduce phlegm and relieve asthma, improve lung function, antibacterial and anti-inflammatory, and regulate immune function. [0003] Although Chanlong Dingchuan Mixture has a definite curative effect, its pharmacological effects and modern studies have shown that ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/48A61K47/14A61K47/26A61K47/44A61P9/00A61P11/00A61P11/06A61P11/10A61P11/14A61P29/00A61P31/04A61P37/02A61K35/413A61K35/62A61K35/65
CPCA61K9/4858A61K35/413A61K35/62A61K35/65A61K36/17A61K36/232A61K36/258A61K36/296A61K36/346A61K36/481A61K36/484A61K36/487A61K36/535A61K36/54A61K36/57A61K36/65A61K36/71A61K36/736A61K36/752A61K36/79A61K36/8888A61K36/9068A61K47/14A61K47/26A61K47/44A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61P9/00A61P11/00A61P11/06A61P11/10A61P11/14A61P29/00A61P31/04A61P37/02A61K2300/00
Inventor 孙波于喜洋于洪懿于淑馨
Owner 锦州福寿堂医药科技有限公司
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