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Application of TOX3 in preparation of kit for predicting AML prognosis

1. The technology of TOX3 and kit, applied in the field of biomedicine, can solve the problems such as the unclear role of TOX3, and achieve the effects of high possibility of poor prognosis, stable method, and good application prospects

Pending Publication Date: 2021-05-07
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although TOX3 is closely related to the prognosis of the above tumors, the role of TOX3 in hematological malignancies, especially leukemia, remains unclear

Method used

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  • Application of TOX3 in preparation of kit for predicting AML prognosis
  • Application of TOX3 in preparation of kit for predicting AML prognosis
  • Application of TOX3 in preparation of kit for predicting AML prognosis

Examples

Experimental program
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Effect test

Embodiment 1

[0056] 1. Peripheral blood was collected under the premise of signing an informed consent form with the patient. Peripheral blood samples from 40 cases of first-onset AML and 29 healthy adults were collected from the Department of Hematology of the First Affiliated Hospital of Jinan University in Guangzhou. All samples were taken from ethylenediaminetetraacetic acid (EDTA) anticoagulation at the time of admission. This part of the research protocol has been obtained. Approved by the Unit Ethics Committee. At the same time, clinical data such as survival time and survival status of AML patients were collected (as shown in Table 1).

[0057] 2. Isolation of mononuclear cells in peripheral blood. Take 4mL of lymphocyte separation medium (Ficoll, density 1.077) and add it into a 15mL centrifuge tube, spread the diluted anticoagulated peripheral blood sample suspension on the separation medium, and centrifuge at 1500rpm for 15 minutes in a horizontal centrifuge. Transfer the sing...

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Abstract

The invention provides application of TOX3 gene in preparation of a kit for predicting AML prognosis. The inventor of the invention discovers that the expression of TOX3 gene in peripheral blood of AML patients is related to the prognosis of AML patients for the first time. When the expression level of TOX3 gene is high, the possibility of poor clinical prognosis of AML patients is high. The expression level of TOX3 gene has important guiding significance for formulating AML early diagnosis and treatment scheme and effective comprehensive hierarchical system, can provide more clinical prognosis research data for targeted therapy of AML patients, and has broad application prospects.

Description

technical field [0001] The invention belongs to the field of biomedicine, and particularly relates to the application of TOX3 in the preparation of a kit for predicting AML prognosis. Background technique [0002] Acute myeloid leukemia (AML) is the most common type of adult leukemia, with an incidence rate of 3.7 / 100,000. At present, the conventional treatment of AML is based on induction of remission and post-remission treatment to the greatest extent. Although in recent years, with the improvement of chemotherapy regimens and the development of hematopoietic stem cell transplantation technology, the treatment of AML patients has achieved certain curative effect. However, there are still problems of high recurrence risk after treatment remission and low disease-free survival rate. Studies have shown that the 5-year overall survival rate of patients under the age of 60 is about 40%, while that of patients over the age of 60 is only 10%-20%, 20% of newly diagnosed patients ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886C12Q1/6851C12N15/11
CPCC12Q1/6886C12Q1/6851C12Q2600/118C12Q2600/158C12Q2600/166C12Q2531/113C12Q2545/101C12Q2521/107
Inventor 陈少华梁朝峰李扬秋查显丰黄舒欣赵玉洁谭家雄
Owner JINAN UNIVERSITY