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Composition and application of composition and irinotecan in preparation of antitumor drugs

An anti-tumor drug, the technology of irinotecan, applied in the field of medicine

Pending Publication Date: 2021-05-11
CHINA PHARM UNIV
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

At present, no studies at home and abroad have shown that vardenafil and / or linagliptin have a synergistic enhancement effect on the anti-colon cancer activity of irinotecan

Method used

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  • Composition and application of composition and irinotecan in preparation of antitumor drugs
  • Composition and application of composition and irinotecan in preparation of antitumor drugs
  • Composition and application of composition and irinotecan in preparation of antitumor drugs

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Embodiment Construction

[0011] The substantive content of the present invention will be described in detail below in conjunction with the embodiments, but the protection scope of the present invention is not limited thereto.

[0012] 1. Experimental materials and reagents

[0013] Cells: human colon cancer HCT-116 cells (Cell Bank, Chinese Academy of Sciences).

[0014] Drugs: Irinotecan (Irinotecan, CPT-11, CAS No.: 97682-44-5), Vardenafil Hydrochloride (Vardenafil, Vard, CAS No.: 330808-88-3), Linagliptin (Linagliptin , Linag, CAS No.:668270-12-0), were purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.

[0015] Reagents: DMEM high glucose medium (Gibco, USA); FBS (Gibco, USA); penicillin-streptomycin (Hyclone, USA); 0.25% trypsin-EDTA solution (Boster, China); PBS (Boster, China) China); DMSO (Sigma-Aldrich, USA); MTT (Beiyuntian, China).

[0016] Consumables: 10cm cell culture dish (SORFA, China); 15, 50mL centrifuge tubes (JET BIOFIL, China); cell cryopreservation tubes (Corning...

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Abstract

The invention discloses a composition and application of the composition and irinotecan in preparation of antitumor drugs. The invention discovers that the composition of vardenafil and linagliptin has a synergistic enhancement effect on the anti-colon cancer activity of irinotecan, and vardenafil or linagliptin independently has no synergistic enhancement effect on the anti-colon cancer activity of irinotecan. Therefore, the composition of vardenafil and linagliptin can be combined with irinotecan to prepare the drugs for resisting colon cancer.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a pharmaceutical composition, in particular to a composition and its use in combination with irinotecan to prepare antitumor drugs. Background technique [0002] Colon cancer is a disease caused by the interaction of genetic and environmental factors and is one of the most common malignant tumors worldwide. Statistics show that in 2020, nearly 150,000 people in the United States are expected to be diagnosed with colon cancer, and about 50,000 people will die from it. The survey found that in China, colon cancer is one of the most common tumors, the incidence rate is second only to lung cancer, and the incidence rate is gradually increasing. Currently, surgery combined with postoperative chemotherapy is the main treatment for colon cancer. However, the efficacy of current chemotherapy drugs needs to be improved. [0003] Irinotecan (CPT-11) is a semi-synthetic water-soluble camptothecin de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/53A61K31/522A61K31/4745A61P35/00
CPCA61K31/53A61K31/522A61K31/4745A61P35/00
Inventor 许风国许瑞洁王笛张培张尊建
Owner CHINA PHARM UNIV
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