Optimized administration method of vancomycin for high MIC bacterial infection of adults

Abstract

The invention provides an optimized drug delivery method of vancomycin for adult high MIC bacterial infection. The method comprises the following steps: 1) establishing a vancomycin optimized two-step infusion method; 2) establishing pharmacokinetic / pharmacodynamic effect indexes and targets related to the clinical curative effect of vancomycin; 3) establishing a mathematical model of the kinetic / pharmacodynamic indexes of the traditional Chinese medicine in the two-step infusion method; 4) establishing a pharmacokinetic parameter model of vancomycin; 5) substituting the pharmacokinetic parameters and administration parameters of vancomycin and the MIC of the target strain into the mathematical model of the pharmacokinetic / pharmacodynamic effect index; 6) running Monte Carlo simulation, and calculating the target obtaining probability of high MIC under the specified pharmacokinetic / pharmacodynamic effect target; and 7) determining an optimized administration scheme according to the target acquisition probability. According to the invention, a proper administration scheme for high MIC is calculated by optimizing an administration mode and utilizing Monte Carlo simulation, so that a doctor can still obtain a better microbiological or clinical curative effect when using vancomycin under high MIC bacterial infection.

Description

technical field [0001] The invention relates to the field of anti-infection treatment, in particular to a clinical administration method. Background technique [0002] At present, the MIC of vancomycin to Gram-positive bacteria such as Enterococcus and Staphylococcus aureus is creeping and drifting, and the resulting vancomycin-insensitive (including intermediate and drug-resistant) Staphylococcus aureus and Enterococcus faecalis and Enterococcus faecium and the infections they cause have seriously threatened human public health and have been included in the priority list by the World Health Organization. The MIC motility of these bacteria not only renders vancomycin progressively inactive, but also severely limits other treatment options, as vancomycin is often the last line of defense for these bacteria. Currently, although some traditional drugs (such as daptomycin, linezolid, quinupristin-dalfopristin, tetracycline, and chloramphenicol) and newer drugs (such as tedizoli...

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Problems solved by technology

[0004] In view of the above-mentioned shortcoming of the prior art, the object of the present invention is to provide a kind of vancomycin is used for the optimal dosing method of adult high MIC bacterial infection, so that vancomycin therapeutic effect is maximized, solves the problem of vancomycin non- In the face of sensitive bacterial infection, but the existing technology can not provide better treatment options, the problem of reduced therapeutic effect of vancomycin

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