Optimized administration method of vancomycin for high MIC bacterial infection of adults

A technology for vancomycin and bacterial infection, which is applied in the field of anti-infection treatment and can solve the problems such as the reduction of the therapeutic effect of vancomycin

Inactive Publication Date: 2021-05-11
HUNAN PROVINCIAL TUMOR HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In view of the above-mentioned shortcoming of the prior art, the object of the present invention is to provide a kind of vancomycin is used for the optimal dosing method of adult high MIC bacterial infection, so that vancomycin t...

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  • Optimized administration method of vancomycin for high MIC bacterial infection of adults
  • Optimized administration method of vancomycin for high MIC bacterial infection of adults
  • Optimized administration method of vancomycin for high MIC bacterial infection of adults

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Embodiment Construction

[0040] Embodiments of the present invention are described below through specific examples, and those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments, and various details (such as parameters) in this specification can also be modified or changed based on different viewpoints and applications without departing from the spirit of the present invention.

[0041] It should be noted that the diagrams provided in the following examples are only schematically illustrating the basic ideas of the present invention, and only the most relevant procedures in the diagram are shown in the diagrams, which can be changed arbitrarily according to the actual situation during actual implementation. The pharmacokinetic parameters of mycin, the infusion rate and infusion time of the first stage of admini...

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Abstract

The invention provides an optimized drug delivery method of vancomycin for adult high MIC bacterial infection. The method comprises the following steps: 1) establishing a vancomycin optimized two-step infusion method; 2) establishing pharmacokinetic/pharmacodynamic effect indexes and targets related to the clinical curative effect of vancomycin; 3) establishing a mathematical model of the kinetic/pharmacodynamic indexes of the traditional Chinese medicine in the two-step infusion method; 4) establishing a pharmacokinetic parameter model of vancomycin; 5) substituting the pharmacokinetic parameters and administration parameters of vancomycin and the MIC of the target strain into the mathematical model of the pharmacokinetic/pharmacodynamic effect index; 6) running Monte Carlo simulation, and calculating the target obtaining probability of high MIC under the specified pharmacokinetic/pharmacodynamic effect target; and 7) determining an optimized administration scheme according to the target acquisition probability. According to the invention, a proper administration scheme for high MIC is calculated by optimizing an administration mode and utilizing Monte Carlo simulation, so that a doctor can still obtain a better microbiological or clinical curative effect when using vancomycin under high MIC bacterial infection.

Description

technical field [0001] The invention relates to the field of anti-infection treatment, in particular to a clinical administration method. Background technique [0002] At present, the MIC of vancomycin to Gram-positive bacteria such as Enterococcus and Staphylococcus aureus is creeping and drifting, and the resulting vancomycin-insensitive (including intermediate and drug-resistant) Staphylococcus aureus and Enterococcus faecalis and Enterococcus faecium and the infections they cause have seriously threatened human public health and have been included in the priority list by the World Health Organization. The MIC motility of these bacteria not only renders vancomycin progressively inactive, but also severely limits other treatment options, as vancomycin is often the last line of defense for these bacteria. Currently, although some traditional drugs (such as daptomycin, linezolid, quinupristin-dalfopristin, tetracycline, and chloramphenicol) and newer drugs (such as tedizoli...

Claims

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Application Information

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IPC IPC(8): G16H20/10G16H70/40
CPCG16H20/10G16H70/40
Inventor 宋香清伍奕潘勇
Owner HUNAN PROVINCIAL TUMOR HOSPITAL
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