Application of small molecule compound in preparation of medicine for preventing or treating pebrine

A technology of small molecular compound and microparticle disease, applied in the fields of molecular biology and pathology, can solve the problems of ineffective effect of silkworm microparticle disease and no significant improvement in the incidence rate, and achieve the effect of reducing the incidence rate and inhibiting replication.
CN112791083AActive Publication Date: 2021-05-14ZHENJIANG COLLEGE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHENJIANG COLLEGE
Publication Date
2021-05-14

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Abstract

The invention provides an application of a small molecule compound in preparation of a medicine for preventing or treating pebrine. The structure of the small molecule compound is as shown in a general formula (I) aiming at core protein of nosema bombycis, and the three-dimensional structure of the small molecule compound is obtained by utilizing a virtual modeling technology based on a mainstream molecular docking technology. The small molecule compound can be used for preparing a medicine for preventing and treating pebrine, when the final use concentration of the small molecule compound in cells is 0.5 [mu]M or above, replication of nosema bombycis can be inhibited, and the morbidity of pebrine can be remarkably reduced when the small molecule compound is added to silkworms with the concentration of 1 mM or above. The method can be used for research, development and production of medicines for preventing and treating pebrine, and has application and popularization values.
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Description

technical field

[0001] The invention relates to the fields of molecular biology and pathology, and relates to the application of a small molecule compound in the preparation of a drug for preventing or treating silkworm micronosis. Background technique

[0002] Silkworm microparticle disease is an ancient and devastating infectious disease of silkworms produced by Nosema bombycis orally infecting silkworms. .

[0003] The study on the chemical treatment of silkworm micronosis has been tried for a long time. It was found that fumagillin and anisomycin have inhibitory effects on the proliferation of the bee micronose protozoan Nosema apis, and benlet has an effect on the alfalfa weevil micron protozoa Nosema apis. The proliferation of sp. can be significantly inhibited, but the effect of these drugs on silkworm microparticle disease is not obvious. At present, the chemotherapeutic drugs used in production in China mainly include Fangweiling, Yuanzhangjing and Yuweiling, but ...

Claims

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