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Viola diffusa volatile oil, extraction and purification method thereof and obtained antitumor drug

A purification method and technology of volatile oil, which is applied in the field of antineoplastic drugs and volatile oil of Corydalis viridifera, can solve the problems of less research on Corydalis viridiflora, and achieve the effects of low cost, low water content and high cytotoxic activity

Pending Publication Date: 2021-05-25
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are few studies on Corydalis persicae, and there is no report on the extraction and use of the volatile oil of Corydalis persinum

Method used

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  • Viola diffusa volatile oil, extraction and purification method thereof and obtained antitumor drug
  • Viola diffusa volatile oil, extraction and purification method thereof and obtained antitumor drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The extraction and purification method of embodiment 1 Corydalis volatile oil

[0022] S1: Take 400g of fresh Corydalis viburnum, wash and dry it, then grind it to a particle size of 60 mesh, add 1200g of distilled water, stir and carry out steam distillation, the distillation extraction time is 4-5h, and obtain a water system containing volatile oil;

[0023] S2: Add ether to the water system containing volatile oil for extraction, discard the separated water layer, add anhydrous sodium sulfate to the ether solution containing volatile oil for dehydration, filter and recover ether, and obtain dry and pure volatile oil with an extraction rate of 1.42% , the water content in the volatile oil is 0.42%.

Embodiment 2

[0024] The extraction and purification method of embodiment 2 Corydalis volatile oil

[0025] S1: Take 400g of fresh Corydalis viburnum, wash and dry it, then grind it to a particle size of 50 mesh, add 800g of distilled water and stir to carry out steam distillation. The distillation extraction time is 5-6 hours, and the water system containing volatile oil is obtained;

[0026] S2: Add ether to the water system containing volatile oil for extraction, discard the separated water layer, add anhydrous sodium sulfate to the ether solution containing volatile oil for dehydration, filter and recover ether, and obtain dry and pure volatile oil with an extraction rate of 1.39% , the water content in the volatile oil is 0.39%.

Embodiment 3

[0027] The extraction and purification method of embodiment 3 Corydalis volatile oil

[0028] S1: Take 400g of fresh Corydalis viburnum, wash and dry it, then powder it to a particle size of 100 mesh, add 1600g of distilled water, stir and carry out steam distillation, the distillation extraction time is 3-4h, and obtain a water system containing volatile oil;

[0029] S2: Add ether to the water system containing volatile oil for extraction, discard the separated water layer, add anhydrous sodium sulfate to the ether solution containing volatile oil for dehydration, filter and recover ether, and obtain dry and pure volatile oil with an extraction rate of 1.37% , the water content in the volatile oil is 0.41%.

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Abstract

The invention provides viola diffusa volatile oil, an extraction and purification method thereof and an obtained antitumor drug, and relates to the technical field of natural products. The extraction and purification method comprises the following steps: crushing viola diffusa, adding water, stirring, and carrying out steam distillation for 3-6 hours to obtain a water system containing volatile oil; adding an organic solvent into the water system containing volatile oil for extraction, discarding a separated water layer, adding a dehydration drying agent into the volatile oil-containing organic solvent for dehydration, and filtering and recovering the organic solvent to obtain dry and pure volatile oil. The viola diffusa volatile oil is extracted and purified by adopting steam distillation and organic extraction technologies for the first time, the extraction and purification method is simple in process and low in cost, and the volatile oil obtained by the preparation process is low in water content, has high cytotoxic activity on human liver cancer cells and human breast cancer cells through experimental verification, and is suitable for industrial production and application.

Description

technical field [0001] The invention relates to the technical field of natural products, in particular to a volatile oil of Corydalis villosa, its extraction and purification method and the obtained antitumor drug. Background technique [0002] Creeping Viola (Viola diffusa Ging), which belongs to the family Violaceae and the genus Viola, is also known as Viola diffusa (Seven Star Lotus). The whole herb is used as medicine for hepatitis, whooping cough, red eyes and swelling; external use for acute mastitis, boils, carbuncle furuncle, herpes zoster, snake bites, bruises. Mainly distributed in Zhejiang Province of my country, it grows in barren slopes, cultivated land, streamsides, under sparse forests and semi-shady wetlands by roadsides. [0003] Volatile oil, also known as essential oil, is a general term for a class of oily liquids that can be volatilized at room temperature, can be distilled with water vapor, and are immiscible with water. Most volatile oils have an ar...

Claims

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Application Information

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IPC IPC(8): C11B9/02C11B9/00A61K36/86A61P35/00
CPCC11B9/022C11B9/025C11B9/027C11B9/0015C11B9/0007A61K36/86A61P35/00A61K2236/331
Inventor 沙沙冯麟杰邢政赵丽华
Owner SHANDONG UNIV
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