New application of nucleotide

Abstract

The invention discloses a new application of nucleotide and an application of the nucleotide in preparation of drugs for preventing and treating diseases such as allergic rhinitis or functional food for relieving symptoms of the allergic rhinitis. The nucleotide is a mixture of five nucleotides, namely CMP, AMP, UMP, GMP and IMP. The molecular weight of the nucleotide is small, absorption of the nucleotide taken by a human body is fast, and bioavailability of the nucleotide is high. It is found that the ingestion of the nucleotide can relieve the symptom of allergic rhinitis of mice, relieve splenomegaly caused by allergy, significantly reduce the histamine level in serum and nasal cavity lavage fluid, and effectively regulate inflammatory factors, thereby playing a role in treating allergic diseases. The nucleotide can be used for preparing medicines for preventing and treating diseases such as allergic rhinitis or functional foods for relieving symptoms of allergic rhinitis, and provides a new way for regulating the immune function in a diet intervention mode.

Description

technical field [0001] The invention relates to the technical field of drug development and the technical field of functional food, in particular to the new application of nucleotides. Background technique [0002] Allergic diseases refer to a class of diseases in which the body produces a large number of antibodies after contact with one or more sensitizing substances (allergens), thereby causing tissue or organ dysfunction or damage, which mainly includes allergic rhinitis, asthma, atopic Dermatitis, allergic gastrointestinal disease and food allergy. Allergic diseases have become a common public health problem, and the incidence is increasing year by year, causing a huge medical burden on patients. At present, the most important treatment for allergic diseases is chemical drug therapy. Although it can alleviate the disease to a certain extent, drug treatment cannot change the process of allergic diseases, and there is no long-term sustained drug effect after stopping the...

AI Technical Summary

Problems solved by technology

At present, the most important treatment for allergic diseases is chemical drug therapy. Although it can alleviate the disease to a certain extent, drug treatment cannot change the process of allergic diseases, and there is no long-term sustained drug effect after stopping the drug. Relapse, and long-term use of chemical drugs may have a negative impact on the body, so it cannot fundamentally achieve the effect of cure

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