Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A novel injectable hydrogel for bone defect repair and preparation method thereof

A technology for bone defect and water injection, applied in pharmaceutical formulations, prostheses, drug delivery, etc., can solve the problems of incompatibility of new bone formation at the degradation rate, affecting the use effect, low gel strength, etc., to improve the effect of bone defect repair , easy to operate, cheap raw materials

Active Publication Date: 2022-04-01
NORTHWEST UNIV
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, hydrogels used in the repair of bone tissue defects usually have disadvantages such as low gel strength, poor toughness, and degradation rates that do not match new bone formation, which have always affected their use.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A novel injectable hydrogel for bone defect repair and preparation method thereof
  • A novel injectable hydrogel for bone defect repair and preparation method thereof
  • A novel injectable hydrogel for bone defect repair and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Dissolve 10 g of dodecylamine in 250 mL of ethanol solution with a mass concentration of 70%, stir until dodecylamine is completely dissolved, then add 6 mL of tetraethyl orthosilicate, 0.34 mL of triethyl phosphate, 3.2 g of calcium nitrate tetrahydrate, 0.55g magnesium nitrate hexahydrate and 0.522g copper nitrate trihydrate, continue to stir for 3h; centrifuge and wash the product with deionized water, freeze-dry, and calcinate the dried powder in the air at 650°C for 3h to obtain magnesium- and copper-rich Bioactive glass.

[0033] The product prepared by scanning electron microscopy is a nanosphere with a particle size of about 650nm to 750nm, such as figure 1 shown; the product nanospheres prepared by transmission electron microscope detection are solid structures, such as figure 2 Shown; The product prepared by X-ray diffraction detection is an amorphous structure, which is a typical feature of silicate glass, such as image 3 Shown; After the powder is immers...

Embodiment 2

[0035] Dissolve 10g of dodecylamine in 250mL of ethanol solution with a mass concentration of 80%, stir until dodecylamine is completely dissolved, then add 40mL of tetraethyl orthosilicate, 0.31mL of triethyl phosphate, 16g of calcium nitrate tetrahydrate, 0.8 g magnesium nitrate hexahydrate and 0.8 g copper nitrate trihydrate, continue to stir for 2 hours; centrifuge and wash the product with deionized water, freeze-dry, and calcinate the dried powder in the air at 600°C for 2 hours to obtain magnesium- and copper-rich bio Active glass, its physical and chemical properties are similar to Example 1.

Embodiment 3

[0037] Dissolve 10 g of dodecylamine in 250 mL of ethanol solution with a mass concentration of 90%, stir until the dodecylamine is completely dissolved, then add 60 mL of tetraethyl orthosilicate, 0.6 mL of triethyl phosphate, 25.5 g of calcium nitrate tetrahydrate, 1.38g magnesium nitrate hexahydrate and 1.3g copper nitrate trihydrate, continue to stir for 4h; centrifuge and wash the product with deionized water, freeze-dry, and calcinate the dried powder in the air at 700°C for 4h to obtain magnesium- and copper-rich Bioactive glass, its physical and chemical properties are similar to Example 1.

[0038] Preparation of injectable hydrogels

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
compressive stressaaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses a novel injectable hydrogel for repairing bone defects. The preparation method comprises the following steps: 1. preparing bioactive glass; 2. preparing collagen grafted with hydrazide bonds and modified oxidized konjac glucomannan Glycan; 3. Disperse the collagen of bioactive glass and grafted hydrazide bonds in PBS solution to obtain liquid A; dissolve the modified oxidized konjac glucomannan in PBS solution to obtain liquid B; 4. A new type of injectable hydrogel for bone defect repair was obtained by mixing liquid A and liquid B. The novel injectable hydrogel for bone defect repair of the present invention has the advantages of in-situ injection, easy operation, less secondary injury caused by surgery, and can adapt to the shape of the defect to realize in-situ filling and molding of the bone defect. bright future.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a novel injectable hydrogel for bone defect repair and a preparation method thereof. Background technique [0002] Bone defects caused by congenital deformities, diseases, traumas and other factors can reach tens of millions of people every year. The development of bone defect repair materials provides a new idea and simple method for the repair of bone defects. The development of bone defect repair materials such as autologous bone, allogeneic bone, inorganic materials such as tricalcium phosphate, organic materials such as silk protein, and organic polymer materials such as polylactic acid provides people with bone repair materials that can adapt to the size and function of different defect parts. , leading to rapid development in this field. For living organisms, the problem of material activity, toxicity, and how to achieve the smallest surgical woun...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/52A61L27/50A61L27/10A61L27/54A61L27/24A61L27/20
CPCA61L27/52A61L27/50A61L27/10A61L27/54A61L27/24A61L27/20A61L2430/02A61L2400/06A61L2300/102A61L2300/412A61L2300/602C08L5/00
Inventor 惠俊峰姚嘉欣范代娣杨孜晨郑晓燕
Owner NORTHWEST UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com