Novel injectable hydrogel for bone defect repair and preparation method thereof

A bone defect and water injection technology, which is applied in pharmaceutical formulations, prostheses, drug delivery, etc., can solve the problems of mismatching degradation rate, new bone formation, affecting the use effect, and low gel strength, so as to improve the repair effect of bone defects , easy operation and cheap raw materials

Active Publication Date: 2021-06-22
NORTHWEST UNIV(CN)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, hydrogels used in the repair of bone tissue defects usually have disadvantages such as low gel strength, poor toughness, and degradation rates that do not match new bone formation, which have always affected their use.

Method used

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  • Novel injectable hydrogel for bone defect repair and preparation method thereof
  • Novel injectable hydrogel for bone defect repair and preparation method thereof
  • Novel injectable hydrogel for bone defect repair and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Dissolve 10 g of dodecylamine in 250 mL of ethanol solution with a mass concentration of 70%, stir until dodecylamine is completely dissolved, then add 6 mL of tetraethyl orthosilicate, 0.34 mL of triethyl phosphate, 3.2 g of calcium nitrate tetrahydrate, 0.55g magnesium nitrate hexahydrate and 0.522g copper nitrate trihydrate, continue to stir for 3h; centrifuge and wash the product with deionized water, freeze-dry, and calcinate the dried powder in the air at 650°C for 3h to obtain magnesium- and copper-rich Bioactive glass.

[0033] The product prepared by scanning electron microscopy is a nanosphere with a particle size of about 650nm to 750nm, such as figure 1 shown; the product nanospheres prepared by transmission electron microscope detection are solid structures, such as figure 2 Shown; The product prepared by X-ray diffraction detection is an amorphous structure, which is a typical feature of silicate glass, such as image 3 Shown; After the powder is immers...

Embodiment 2

[0035] Dissolve 10g of dodecylamine in 250mL of ethanol solution with a mass concentration of 80%, stir until dodecylamine is completely dissolved, then add 40mL of tetraethyl orthosilicate, 0.31mL of triethyl phosphate, 16g of calcium nitrate tetrahydrate, 0.8 g magnesium nitrate hexahydrate and 0.8 g copper nitrate trihydrate, continue to stir for 2 hours; centrifuge and wash the product with deionized water, freeze-dry, and calcinate the dried powder in the air at 600°C for 2 hours to obtain magnesium- and copper-rich bio Active glass, its physical and chemical properties are similar to Example 1.

Embodiment 3

[0037] Dissolve 10 g of dodecylamine in 250 mL of ethanol solution with a mass concentration of 90%, stir until the dodecylamine is completely dissolved, then add 60 mL of tetraethyl orthosilicate, 0.6 mL of triethyl phosphate, 25.5 g of calcium nitrate tetrahydrate, 1.38g magnesium nitrate hexahydrate and 1.3g copper nitrate trihydrate, continue to stir for 4h; centrifuge and wash the product with deionized water, freeze-dry, and calcinate the dried powder in the air at 700°C for 4h to obtain magnesium- and copper-rich Bioactive glass, its physical and chemical properties are similar to Example 1.

[0038] Preparation of injectable hydrogels

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Abstract

The invention discloses novel injectable hydrogel for bone defect repair. A preparation method of the novel injectable hydrogel comprises the steps: 1, preparing bioactive glass; 2, preparing hydrazide bond-grafted collagen and modified oxidized konjac glucomannan; 3, dispersing the bioactive glass and the hydrazide bond-grafted collagen in a PBS solution to obtain a solution A; dissolving the modified oxidized konjac glucomannan in a PBS solution to obtain a solution B; and 4, mixing the solution A and the solution B to obtain the novel injectable hydrogel for bone defect repair. The novel injectable hydrogel for bone defect repair has the advantages that in-situ injection can be achieved, operation is easy and convenient, secondary injury generated by an operation is small, the hydrogel can adapt to the shape of a defect part, in-situ filling forming of the bone defect part is achieved, and the application prospect is wide.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a novel injectable hydrogel for bone defect repair and a preparation method thereof. Background technique [0002] Bone defects caused by congenital deformities, diseases, traumas and other factors can reach tens of millions of people every year. The development of bone defect repair materials provides a new idea and simple method for the repair of bone defects. The development of bone defect repair materials such as autologous bone, allogeneic bone, inorganic materials such as tricalcium phosphate, organic materials such as silk protein, and organic polymer materials such as polylactic acid provides people with bone repair materials that can adapt to the size and function of different defect parts. , leading to rapid development in this field. For living organisms, the problem of material activity, toxicity, and how to achieve the smallest surgical woun...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/52A61L27/50A61L27/10A61L27/54A61L27/24A61L27/20
CPCA61L27/52A61L27/50A61L27/10A61L27/54A61L27/24A61L27/20A61L2430/02A61L2400/06A61L2300/102A61L2300/412A61L2300/602C08L5/00
Inventor 惠俊峰姚嘉欣范代娣杨孜晨郑晓燕
Owner NORTHWEST UNIV(CN)
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