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Low odor or no odor inhaler desiccant polymer

An odor absorption, polymer technology, used in inhalers, drug delivery, drug devices, etc., can solve problems such as unpleasantness and unsuitability for users

Pending Publication Date: 2021-06-25
CSP TECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, one problem with known aspirators is that they often emit an odor that is unpleasant to the user, making them unsuitable for use

Method used

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  • Low odor or no odor inhaler desiccant polymer
  • Low odor or no odor inhaler desiccant polymer
  • Low odor or no odor inhaler desiccant polymer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Desiccant-entrained polymer resins M-3050 and M-3057 were prepared according to the following:

[0071]

[0072] A reference desiccant-entraining polymer M-3003 was also prepared according to the following:

[0073] components Function content(%) Molecular Sieve 4A desiccant 69 Poly(ethylene) glycol Channeling agent 5 Polypropylene base polymer 24 Titanium dioxide Colorant 2

Embodiment 2

[0075] Desiccant-entraining polymers M-3050, M-3057 and reference polymer M-3003 were used as materials for sleeves in vials, respectively, and then extruded into vials to form sleeved vials M- 3050-451, M-3057-451 and M-3003-451. Dimensions for vials and cartridges are as follows:

[0076] Dimensions typical value volume 166mL Total Vial Height 101mm Vial internal height 96mm Vial outer diameter 52mm Sleeve inner diameter 47mm

Embodiment 3

[0078] Three vials each of M-3050-451 (sleeve weight approximately 16 grams) and M-3003-451 (sleeve weight approximately 16 grams), plus a vial of polymer without entrained desiccant as a blank, each in an aluminum press Cover tightly and place in a 140°F (60°C) oven overnight. The concentration of volatile organic compounds (VOCs) was measured as a measure of the odor emitted from the vials by analyzing the gas in the headspace of each vial by GCMS with a photoionization detector.

[0079] The results are shown in Figure 10 middle. Vials with optional desiccant entrapped polymeric sleeves of the present invention emitted significantly less odor than the reference vials and were comparable to the undried vials.

[0080] Odor tests on human subjects showed that the blank sample (undried vial) was slightly more odorous than the M-3050-451 vial, which emitted a very faint, almost odorless (i.e., no odor or almost no odor).

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Abstract

An inhaler includes a body portion defining a flow path for the administration of medicament to a patient, and an entrained polymer in the flow path and being secured to or integral with the body portion. The entrained polymer has a monolithic material that includes a base polymer, an active agent (e.g., desiccant and optionally odor adsorber), and optionally a channeling agent. Optionally, the entrained polymer in a 16 gram quantity releases less than 4 parts per million volatile organic compounds after heating at 60 DEG C for up to 72 hours, optionally zero parts per million.

Description

technical field [0001] The present disclosure relates to inhalers, and more particularly to inhalers having desiccants configured to produce reduced amounts of volatile odors compared to existing dry inhalers. Optionally, the desiccant in the inhaler of the disclosed concept is odorless or substantially odorless. Background technique [0002] Many items are preferably stored, transported and / or utilized in an environment that must be controlled and / or regulated. For example, in the field of moisture management, it has been recognized that containers and / or packages having the ability to absorb excess moisture trapped therein are desirable. In medical, electronics and food packaging applications, control of moisture, oxygen, ethylene and other gaseous species may be required. [0003] Conventionally, desiccants, oxygen absorbers and other active agents have been used in raw form, for example as loose granules contained in pouches or cans within the package, to control the i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/10A61K47/02
CPCA61K9/008A61K47/10A61K47/02A61M15/0001A61M15/009A61M2207/00
Inventor T·斯特林格W·艾布拉姆斯G·彼得斯
Owner CSP TECH INC