A kind of salicylic acid O-carboxylic acid anhydride ring-opening polymerization-induced method for synthesizing self-assembled nanobody
A technology of ring-opening polymerization and carboxylic anhydride, which is applied in the field of self-assembled nanobody induced by ring-opening polymerization of salicylic acid O-carboxylic anhydride, which can solve the problems of wide molecular weight distribution, low polymer molecules, and high energy consumption at high temperature.
Active Publication Date: 2022-05-27
BEIJING UNIV OF CHEM TECH
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Problems solved by technology
At present, there are few studies on polysalicylic acid, mainly synthesized by melt condensation [3,4,5] , the whole polymerization process requires high temperature and energy consumption, and the generated polymer molecules are low and the molecular weight distribution is wide
Method used
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Embodiment 1
[0033] 1 equivalent of ribose was added to the reaction tube, 1 mL of ethyl acetate was added, 1 equivalent of TMEDA was added, and 100 equivalents of monomer were added after stirring for 10 minutes. Assembly behavior.
Embodiment 2
[0035] 1 equivalent of glucose was added to the reaction tube, 1 mL of ethyl acetate was added, 2 equivalents of TMEDA was added, 100 equivalents of monomer were added after stirring for 10 minutes, and the reaction was carried out at 30 °C. Assembly behavior.
Embodiment 3
[0037] 1 equivalent of fructose was added to the reaction tube, 1 mL of ethyl acetate was added, 2 equivalents of TMEDA were added, and 100 equivalents of monomer were added after stirring for 10 minutes. Assembly behavior.
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The invention discloses a method for synthesizing self-assembled nano-body induced by ring-opening polymerization of salicylic acid O-carboxylic acid anhydride, which belongs to the field of nano-delivery system. The present invention uses salicylic acid O-carboxylic acid anhydride as raw material, uses hydrophilic biomolecules as initiator in a selective solvent, and under organic base catalysis, synthesizes a nano-delivery system with physiological drug effect by self-assembly induced by polymerization. This method has the advantages of convenient operation, controllable process and high reaction rate, and provides a new way for the synthesis of functional drug delivery systems.
Description
technical field [0001] The invention belongs to the field of nano-delivery systems, and discloses a new method for synthesizing nano-materials with physiological efficacy by inducing self-assembly through ring-opening polymerization of salicylic acid O-carboxylic anhydride, and specifically relates to a method that under suitable temperature, Using salicylic acid O-carboxylic acid anhydride as raw material, through ring-opening polymerization, hydrophilic biomolecules are used as initiators in selective solvents, and under the catalysis of an appropriate proportion of organic bases, the polymerization-induced self-assembly synthesis has its own physiological efficacy. method of nanomaterials. Background technique [0002] Two-step preparation of block polymer nanoaggregates by traditional method [1] , firstly, the synthesis and purification of the polymer chain are carried out, and then the polymer chain is assembled by the method of direct dissolution or solvent switching,...
Claims
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IPC IPC(8): C08G67/04
CPCC08G67/04
Inventor 杨晶石倩倩
Owner BEIJING UNIV OF CHEM TECH