Compound temperature-sensitive gel, preparation method and application thereof

Abstract

The invention discloses compound temperature-sensitive gel, a preparation method and application thereof. The compound temperature-sensitive gel is prepared from the following components in percentage by weight: 0.5% of indigo naturalis extract, 0.5% of gallnut extract, 0.025% of sarcandra glabra extract, 0.5% of vitamin E, 2% of ethanol, 0.5-3.0% of borneol, 10-30% of gel matrix, 0.05% of preservative, 0.05% of flavoring agent and the balance of water. According to the invention, the compound temperature-sensitive gel has the advantages of smooth appearance, transparency, fineness, proper consistency and viscosity and the like, can immediately generate phase transformation at the administration part after administration, can be converted from a liquid state to form a non-chemically crosslinked semisolid gel preparation, has good histocompatibility, can be resisted for a long time at the administration part, has the effects of storing medicines, achieving slow release, preventing medicine from being influenced by environment and like, is high in bioavailability, lasting in drug effect time and good in patient compliance, and has good research and development value in treatment of recurrent oral ulceration.

Description

technical field [0001] The embodiments of the present invention relate to the technical field of medicine, in particular to a compound thermosensitive gel and its preparation method and application. Background technique [0002] Recurrent oral ulceration (ROU) is the most common ulcer disease among oral mucosal diseases, accounting for about 20% of the population. The disease shows periodic attacks and is self-limiting. In mild cases, it occurs once every few months, and in severe cases, it is chronic and protracted, with recurrent attacks. The etiology of ROU is complex, usually associated with excessive fatigue, lack of sleep, indigestion, infection, mucosal trauma, autoimmune diseases, food and contact allergies, as well as psychological, genetic and environmental factors. [0003] ROU is the most common oral mucosal disease with a high incidence and easy recurrence. Due to the complex etiology and unclear pathogenesis, although there are many treatment methods, so far, ...

AI Technical Summary

Problems solved by technology

Topical medication has the disadvantages of being greatly affected by saliva, acting on the lesion for a short time, and local effective drug concentration is low. The film formulations and sustained-release formulations developed in recent years can firmly adhere to the mucous membrane through the adhesive components, and to a certain extent It resists the clearing effect of saliva and swallowing, which is conducive to prolonging the action time of the drug and better exerting the drug effect, but the administration of film preparations and sustained-release preparations is very inconvenient, and the patient's compliance is not good, so the administration is changed Form is an effective way to treat recurrent oral ulcers

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