Method for preparing three-axis concentric nanofiber based on controllable drug release

A nanofiber and drug technology, which is applied in the field of triaxial co-core nanofiber preparation, can solve the problems of drug release depending on the degradation rate, the difficulty of drug release and degradation rate, and the inability to meet the needs of long-acting drug efficacy, and achieve excellent biocompatibility. compatibility with organic polymers, excellent biocompatibility and spinnability, and the effect of improving the efficiency of drug use

Pending Publication Date: 2021-07-02
SHANGHAI UNIV OF ENG SCI
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

However, the traditional way of administration has disadvantages. For example, in the initial stage of administration, the drug carrier enters the blood, and because the concentration of the drug is very high, it is easy to exceed the patient's tolerance dose and cause toxic and side effects.
The preparation of core-shell structures by electrospinning technology is mainly divided into two methods: emulsion electrospinning and coaxial electrospinning, as documented in patent publications CN109576812A, CN111991343A, CN107620132A and CN101509153A, but drug release depends entirely on the properties of the cortical material. Degradation rate, it is difficult to obtain the ideal drug release degradation rate
Yang et al. pr

Method used

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  • Method for preparing three-axis concentric nanofiber based on controllable drug release
  • Method for preparing three-axis concentric nanofiber based on controllable drug release
  • Method for preparing three-axis concentric nanofiber based on controllable drug release

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preparation example Construction

[0035] Such as figure 2 As shown, an exemplary method for preparing a triaxial concentric nanofiber based on drug release controllable is described, and the steps are as follows:

[0036] (1) Oil phase preparation: polycaprolactone is dissolved in chloroform, then a certain volume of surfactant sorbitan monooleate is dropped into it, and the rotating speed is 400-700r / min constant temperature magnetic stirring for 2h to obtain the mass Oily phase with a fraction of 8%-10%;

[0037] (2) Water phase preparation: tetracycline hydrochloride is dissolved in deionized water, and the rotating speed is 400-700r / min constant temperature magnetic stirring for 5-10min, until tetracycline hydrochloride is completely dissolved, and tetracycline hydrochloride aqueous solution is obtained. 8%-10%;

[0038] (3) Emulsion preparation: the tetracycline hydrochloride aqueous solution of step (2) is gradually added dropwise into the oil phase of step (1) through a micro-sampler to form a water-oi...

Embodiment

[0043] Preparation of triaxial concentric nanofibers based on controlled drug release, the steps are as follows:

[0044] (1) Polycaprolactone was dissolved in chloroform, then 20 μL of Span80 was added dropwise, and the mass volume fraction of the oil phase was prepared to be 8%, the stirring speed was selected to be 600 r / min, and the stirring time was 2 h.

[0045] (2) Tetracycline hydrochloride was dissolved in deionized water, the tetracycline hydrochloride solution accounted for 8%-10% of the volume fraction of deionized water, the stirring speed was selected to be 600r / min, and the stirring time was 10min.

[0046] (3) The tetracycline hydrochloride aqueous solution is gradually added dropwise into the oil phase to form a core layer emulsion with a water-oil phase volume ratio of 6%, the stirring intensity is 20% amplitude, and the stirring time is 10min.

[0047] (4) Polyvinylpyrrolidone was dissolved in N,N-dimethylformamide to prepare a shell spinning solution with a...

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Abstract

The invention discloses a method for preparing three-axis concentric nanofiber based on controllable drug release, and belongs to the technical field of functional textiles. The preparation method comprises the following steps of dissolving polycaprolactone in trichloromethane, dropwise adding sorbitan monooleate, stirring to obtain an oil phase, dissolving tetracycline hydrochloride in deionized water to obtain a tetracycline hydrochloride aqueous solution, weighing the tetracycline hydrochloride aqueous solution, gradually dropwise adding the tetracycline hydrochloride aqueous solution into the oil phase, forming an emulsion under the condition of stirring with an ultrasonic probe to serve as a core layer spinning solution, dissolving polyvinylpyrrolidone into N,N-dimethylformamide to obtain a uniform bubble-free shell layer spinning solution, connecting the core layer spinning solution with an inner cavity of a coaxial spinning nozzle, connecting the shell layer spinning solution with an outer cavity of the coaxial spinning nozzle, and performing electrostatic spinning through spraying of the coaxial spinning nozzle. The three-axis concentric nanofiber is prepared by combining emulsion electrostatic spinning with coaxial electrostatic spinning, the operation is simple, the reaction condition is mild, and the use efficiency of drugs can be improved through a multistage drug sustained-release system.

Description

technical field [0001] The invention belongs to the technical field of functional textiles, and in particular relates to a method for preparing triaxial concentric nanofibers based on controllable drug release. Background technique [0002] Traditional drug sustained-release systems are mainly divided into the following three forms according to different drug release methods and release mechanisms: homogeneous mixed drug controlled release system in which the drug is uniformly mixed in the polymer matrix, and the drug is physically embedded in the polymer matrix. The accumulative drug controlled release system in the polymer membrane and the polymer drug controlled release system that combines the drug with the polymer by chemical bonds. However, there are disadvantages in the traditional way of administration. For example, in the early stage of administration, the drug enters the blood through the drug carrier. Because the concentration of the drug is very high, it is easy ...

Claims

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Application Information

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IPC IPC(8): D01F8/14D01F8/10D01D5/34A61K9/70A61K47/34A61K47/32A61K31/65A61P17/02A61P1/02B82Y30/00B82Y40/00
CPCD01F8/14D01F8/10D01D5/34A61K9/70A61K47/34A61K47/32A61K31/65A61P17/02A61P1/02B82Y30/00B82Y40/00
Inventor 刘毅辛斌杰李庭晓
Owner SHANGHAI UNIV OF ENG SCI
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