Mass spectrometry device and method for online analysis of isomeride mixture

Abstract

The invention provides a mass spectrometry device and method for online analysis of an isomeride mixture. The mass spectrometry device comprises a closed container, five plate-shaped electrodes are sequentially arranged in the container from left to right in parallel at intervals, through holes are formed in the middles of the plate-shaped electrodes, the peripheral edges of the plate-shaped electrodes are connected with the inner wall face of the container in a closed mode, and the container is divided into an ionization source cavity, an ion mobility spectrometry cavity, a collision pool cavity, a radio frequency transmission area cavity, an electrostatic lens cavity and a mass analyzer cavity which are sequentially and adjacently arranged from left to right.. The on-line analysis method of the isomeride comprises the following steps: generating molecular ions / quasi-molecular ions of an object to be detected by using a soft ionization source, carrying out one-dimensional separation on the isomeride ions with different space structures by using an ion mobility spectrometry, detecting the molecular weight of a compound by using a mass spectrometer, obtaining molecular functional groups and structural information by dissociating compound ions through a collision pool, and finally achieving online analysis of the isomeride mixture.

Description

technical field [0001] The invention relates to a mass spectrometry analysis instrument and method, in particular to a mass spectrometry device and method for on-line analysis of isomer mixtures. Specifically, the ion mobility spectrometry with the ability to resolve the molecular space structure of the compound and the mass spectrometer with the ability to analyze the molecular mass are combined, and combined with the dissociation of the compound ion by the collision cell to obtain molecular functional groups and structural information, in order to achieve isomerism On-line analysis of body mixtures. Background technique [0002] Isomers are a class of compounds that have the same molecular formula but different arrangements of atoms, that is, have the same molecular formula but different structures. Isomers have different molecular structures, resulting in different physical and chemical properties. Isomerism is one of the reasons for the huge variety of organic compound...

AI Technical Summary

Problems solved by technology

However, isomers have the same molecular formula, that is, the same molecular weight, and often only appear as a single mass spectrum peak with the same mass-to-charge ratio in the soft ionization mass spectrum. The absence of characteristic fragment ion peaks makes it impossible to obtain molecular structure-related information, so Difficult to achieve accurate characterization of isomers

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