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Cefquinome injection as well as preparation method and application thereof

A technology of cefquinome and cefquinome sulfate, which is applied in liquid transportation, pharmaceutical formula, emulsion transportation, etc., can solve the problems of large animal stress, sedimentation agglomeration, discoloration, etc. release effect

Inactive Publication Date: 2021-07-16
LUOYANG HUIDE BIO ENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the products currently on the market have problems such as sedimentation, agglomeration, discoloration, and animal stress to varying degrees, which limit their wide application in animal husbandry.

Method used

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  • Cefquinome injection as well as preparation method and application thereof
  • Cefquinome injection as well as preparation method and application thereof
  • Cefquinome injection as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1, cefquinome suspension of the present invention and preparation method thereof

[0027] The main drug raw material used in samples 1-4 in this example is superfine powder of cefquinoxime sulfate, and the crushing equipment is a QYF-2600 jet mill, purchased from Kunshan Miyou Machinery Manufacturing Co., Ltd. When working, the pressure of the air compressor is 0.4MPa, the speed of the classification wheel is 7200 rpm, the crushing pressure of the main air valve is 0.8MPa, the pressure of the blowback valve is 0.4-0.6MPa, and the crushing speed is 5-10g / s. The particle size of the crushed raw material is 0.1-50 μm.

[0028] The preparation method of samples 1 to 4 in this embodiment: medium-chain fatty acid triglycerides are added with fumed nano-silica and diglyceryl dioleate, 0.22 micron filter membrane is sterilized and filtered, and then micronized cefquinone sulfate is added For oxime, turn on the high-shear equipment and high-shear for 30 minutes, and ...

Embodiment 2

[0042] The appearance inspection of embodiment 2, cefquinome suspension injection sample

[0043] Take samples 1, 2, 3, 4 of the present invention prepared in Example 1 and control sample 5 to observe their appearance properties and wall hanging phenomenon, measure their sedimentation volume ratio and viscosity, and evaluate the appearance quality. For the determination method of sedimentation volume ratio and content, refer to the 2015 edition of "The Veterinary Pharmacopoeia of the People's Republic of China".

[0044] The quality check of the sample that table 1 embodiment 1 prepares

[0045]

[0046] As can be seen from Table 1, the appearance of samples 1, 2, 3, 4 of the present invention and control sample 5 is a milky white liquid, and only the control sample 5 has a slight wall hanging phenomenon after shaking; the average particle size of the control sample 5 is greater than 50 μm, while the other samples The average particle size is all less than 15 μm; the sedim...

Embodiment 3

[0047] Embodiment 3, redispersibility detection

[0048] Get each 20ml of samples 1, 2, 3, 4 of the present invention prepared in Example 1 and control sample 5, place in a 50ml centrifuge tube, centrifuge at 8000r / min for 30min, make it precipitate, shake up and down, observe the suspension again Number of shakes for uniform dispersion.

[0049]Table 2 Shaking times for suspension injection sample redispersion

[0050] Sample serial number sample 1 sample 2 sample 3 Sample 4 Sample 5 Number of shakes 3 times 3 times 3 times 3 times 11 times

[0051] It can be seen from Table 2 that after centrifugation, sample 5 was evenly dispersed after 11 shakes; samples 1, 2, 3, and 4 could be dispersed evenly after only 3 shakes, and the redispersibility was good, and the shaking There is no "wall-hanging imagination", indicating that the sample prepared by the method of the present invention has better redispersibility. The "wall-hanging imaginat...

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Abstract

The invention provides a cefquinome suspension injection. The cefquinome suspension injection contains cefquinome, an anti-caking agent and a suspending aid, the anti-caking agent is nanoscale silicon dioxide, the suspending aid is dipolyglycerol dioleate, the content of the nanoscale silicon dioxide is 0.5 w / v%-3w / v%, and the content of the dipolyglycerol dioleate is 0.5 w / v%-3w / v%. The cefquinome suspension injection is not easy to settle, good in stability, good in redispersibility, easier to release, not easy to generate stress, and beneficial to clinical use.

Description

technical field [0001] The invention relates to a cefquinome injection and a preparation method thereof, belonging to the field of veterinary medicine. Background technique [0002] Cephalosporins are a class of antibiotics widely used in clinical practice. Cefquinoxime is the fourth generation of cephalosporins specially used for animals. It has the advantages of broad antibacterial spectrum, strong antibacterial effect and low toxicity. Clinically, it is mainly used for the treatment of respiratory diseases of pigs and cattle, as well as mastitis and endometritis of dairy cows and sows. Compared with other similar products, cefquinome is a new type of antibiotic, which has many advantages such as small dosage, low toxicity and side effects, and remarkable curative effect, so it has strong use value. [0003] Pharmacokinetic data show that: cefquinome is poorly absorbed orally, and its sulfate salt is commonly used in clinical practice to make suspension injection or ointm...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/546A61K47/04A61K47/10A61K47/14A61P31/04
CPCA61K9/0019A61K9/10A61K31/546A61K47/02A61K47/10A61K47/14A61P31/04
Inventor 雷海昌李冬冬梁立钦于利红刘飞鸟
Owner LUOYANG HUIDE BIO ENG CO LTD
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