Method for resisting Alzheimer's disease by using fructus rosae laevigatae triterpenoid

Abstract

The invention discloses a method for resisting Alzheimer's disease by using a fructus rosae laevigatae triterpenoid and relates to a method for resisting Alzheimer's disease by using a biological compound. The method comprises the following steps: obtaining pharmacological targets of fructus rosae laevigatae and pathogen targets of Alzheimer's disease through online database or website analysis, and then converting collected compounds from 2D to corresponding 3D structures by using software; carrying out molecular docking, and screening and storing compounds with good docking results; obtaining a drug-disease intersection target gene target spot, and constructing a related protein interaction network to screen a core target spot; carrying out gene ontology GO biological process and KEGG pathway enrichment analysis on the core target spot by utilizing an R language related package; constructing a drug-target-disease pathway graph for deep analysis of a treatment mechanism, and further confirming the authenticity of network pharmacology through in-vitro activity verification. The invention aims to provide a new thought for researching the Alzheimer's disease, and provides an earlier-stage research basis for clinical application of the rosa laevigata triterpenoids to the Alzheimer's disease.

Description

technical field [0001] The present invention relates to a method for anti-Alzheimer's disease of biomedical compounds, in particular to a method for anti-Alzheimer's disease of Fructus Rosa triterpenoids, specifically a method for analyzing Fructus Rosa Fructus based on network pharmacology Approaches to the mechanism of action of triterpenoids against Alzheimer's disease. Background technique [0002] Alzheimer's disease (AD) is a primary central nervous system degenerative disease characterized by progressive cognitive dysfunction and memory impairment, which mainly occurs in the presenile and old age, and seriously affects the quality of life and quality of life of the elderly. independence. The pathological features of AD are mainly a large number of senile plaques (SP) neurofibrillary tangles (NFTs) in the brain and selective loss of neurons and synapses in specific brain regions". At present, there is no cure for AD at home and abroad. The medicine plays an increasin...

AI Technical Summary

Problems solved by technology

At present, there is no cure for AD at home and abroad. Traditional Chinese medicine treats AD through syndrome differentiation and the use of compound prescriptions, from different targets and different ways.

Images