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Application of learning and memory ability medicine for treating Alzheimer's disease

A technology for learning and memory ability and Alzheimer's disease. It is applied in the direction of drug combination, pharmaceutical formula, active ingredients of hydroxyl compounds, etc. It can solve problems such as spending a lot of time and failing to delay disease progression.

Active Publication Date: 2021-08-10
江西亿森傲游医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing drugs available for clinical use can only achieve partial relief of symptoms (such as memantine), and cannot delay the progression of the disease
The lack of AD prevention and treatment drugs makes families and society have to spend a lot of time caring for AD patients and other dementia patients in daily life, etc.

Method used

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  • Application of learning and memory ability medicine for treating Alzheimer's disease
  • Application of learning and memory ability medicine for treating Alzheimer's disease
  • Application of learning and memory ability medicine for treating Alzheimer's disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: 1,2,4-trimethoxybenzene (B4) improves the learning and cognitive ability of AD model fruit flies

[0030] The test results are shown in the attached figure 1 :

[0031] Such as figure 1 As shown, compared with wild-type Drosophila, the ability of Aβ transgenic AD model Drosophila to avoid electric shocks according to odor information was significantly reduced, indicating the loss of olfactory memory ability. After the administration of the positive control drug memantine, the ability of the Aβ transgenic AD model fruit flies to avoid electric shocks according to the odor information was significantly improved, indicating that memantine partially relieved the memory ability of the AD model fruit flies. At the same time, after another group of AD model flies were given 1,2,4-trimethoxybenzene, their ability to avoid electric shocks according to odor information was also significantly improved, indicating that 1,2,4-trimethoxybenzene can improve The learning ...

Embodiment 2

[0032] Embodiment 2: α-terpineol (A4) improves the learning cognitive ability of AD model Drosophila

[0033] The test results are shown in the attached figure 2 :

[0034] Such as figure 2 As shown, compared with wild-type Drosophila, the ability of Aβ transgenic AD model Drosophila to avoid electric shocks according to odor information was significantly reduced, which indicated that these Drosophila lost the ability of olfactory memory. After being given the positive control drug memantine, the ability of the Aβ transgenic AD model fruit flies to avoid electric shocks according to the odor information was significantly recovered, which indicated that memantine partially alleviated the memory ability of the AD model fruit flies. At the same time, after giving α-terpineol to another group of AD model flies, their ability to avoid electric shocks according to the odor information was also significantly improved, which indicates that α-terpineol can improve the learning and ...

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Abstract

The invention provides an application of 1, 2, 4-trimethoxybenzene or alpha-terpilenol as shown in a formula 1 or a formula 2 in the specification in a learning and memory ability medicine for treating the Alzheimer's disease, pavlovian olfactory memory detection carried out by an A beta transgenic fruit fly model prepared by an elav-Gal4 promoter shows that after 1, 2, 4-trimethoxybenzene or alpha-terpilenol is given to AD model fruit flies, the electric shock avoiding capability of the AD model fruit flies according to odor information is also remarkably improved, the 1, 2, 4-trimethoxybenzene or alpha-terpilenol can improve the learning and cognition ability of AD model fruit flies, and it is revealed that 1, 2, 4-trimethoxybenzene or alpha-terpilenol can be used for preparing the medicine for treating AD.

Description

technical field [0001] The invention relates to a medicine, in particular to a medicine for treating learning and memory defects of Alzheimer's disease. Background technique [0002] As people age, the incidence of aging-related diseases increases year by year. Among them, dementia diseases, mainly Alzheimer's disease (AD), occupy a dominant position in neurodegenerative diseases. Alzheimer's disease is a neurodegenerative disease characterized by comprehensive dementia such as memory impairment, aphasia, apraxia, agnosia, impairment of visuospatial skills, executive dysfunction, and changes in personality and behavior. Dementia. [0003] According to the latest statistics, there are more than 50 million dementia patients in China. The incidence rate of people over 60 years old diagnosed with AD is 3.94%. The high incidence of AD and the decline in the self-care ability of AD patients have brought great burdens to society and families. The existing drugs available for c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/09A61K31/045A61P25/28
CPCA61K31/09A61K31/045A61P25/28A61K2300/00
Inventor 张海燕袁增强
Owner 江西亿森傲游医药科技有限公司
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