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Water-based emulsion containing methylene blue vital dye, application of emulsion and pharmaceutical composition containing emulsion

A technology of vital dye and methylene blue, which is applied in the field of treating solid tumors and achieves the effects of convenient preparation, low oil concentration, and increased available dose

Pending Publication Date: 2021-08-10
CHENGDU KUACHANGAOPU MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Therefore, in order to improve the stability of injection emulsions containing oil and water or / and reduce the oil concentration (dosage) that must be used, it is necessary to develop new emulsification enhancement technology to meet this demand that the existing technology cannot meet

Method used

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  • Water-based emulsion containing methylene blue vital dye, application of emulsion and pharmaceutical composition containing emulsion
  • Water-based emulsion containing methylene blue vital dye, application of emulsion and pharmaceutical composition containing emulsion
  • Water-based emulsion containing methylene blue vital dye, application of emulsion and pharmaceutical composition containing emulsion

Examples

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preparation example Construction

[0039] According to the preparation method of the present invention, the preparation of the aqueous emulsion of the present invention comprises the following steps: 1) preparing an aqueous solution comprising the methylene blue vital dye and optional water-soluble other components; 2) preparing an aqueous solution comprising The oil solution of the fat and other oil-soluble components optionally present; 3) fully mixing the aqueous solution prepared in step 1) with the oil solution prepared in step 2).

[0040] According to the preparation method of the present invention, the preparation of the pharmaceutical composition of the present invention at least comprises the following steps: 1) preparing the preparation comprising the methylene blue vital dye, the antineoplastic drug (if a water-soluble antineoplastic drug is selected) and optionally an aqueous solution of said water-soluble other components present; 2) preparation comprising said oil, said antineoplastic drug (if an ...

Embodiment 1

[0063] Embodiment 1: the preparation of water-based emulsion

[0064] According to the preparation method of the above-mentioned water-based emulsion of the present invention, many different water-based emulsions of the present invention can be prepared. The composition of some water-based emulsions of the present invention prepared in this example is listed in Table 2.

[0065] Table 2

[0066] serial number grease Methylene blue vital dyes aqueous solvent 1 5% lipiodolized oil 1% methylene blue 94% water 2 1% Lipiodolized Oil / 4% Ethyl Oleate 1% methylene blue 94% water 3 1% Lipiodol / 4% Castor Oil 1% methylene blue 94% water

[0067] Several examples of preparation tests of the water-based emulsion of the present invention are listed below.

[0068] For example, the methylene blue vital dye (for example, 1 g of methylene blue), fat (for example, 5 g of lipiodol), and 94 ml of water in the pharmaceutical composition are meas...

Embodiment 2

[0069]Embodiment 2: Preparation of the water-based emulsion composition comprising conventional antineoplastic drugs

[0070] According to the above-mentioned preparation method of the pharmaceutical composition containing conventional antitumor drugs of the present invention, many different water-based emulsion compositions containing antitumor drugs of the present invention can be prepared. The composition of some water-based emulsion compositions of the present invention prepared in this example is listed in Table 3.

[0071] table 3

[0072]

[0073]

[0074] Several examples of preparation tests of the water-based emulsion containing conventional antineoplastic drugs of the present invention are listed below.

[0075] For example, measure the methylene blue vital dye (such as 1g methylene blue), oil (such as 2.5g lipiodol, 7.5g ethyl oleate), water (such as 73.5ml) in the pharmaceutical composition according to the required concentration. And non-water-soluble con...

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Abstract

The invention relates to a stable water-based emulsion, which contains methylene blue vital dye and grease, and in the emulsion, the concentration of the grease is less than 50 wt%, and the weight ratio of the methylene blue vital dye to the grease is greater than 1 / 75 or (1-75) / 75, preferably greater than or equal to 1 / 37.5 or (1-37.5) / 37.5. The invention also relates to an application and a preparation method of the emulsion, and a pharmaceutical composition containing the emulsion.

Description

technical field [0001] The disclosure of the present application relates to a water-based emulsion containing methylene blue vital dyes, the application of the emulsion, a pharmaceutical composition containing the emulsion, and a method for treating solid tumors comprising administering the water-based emulsion or the pharmaceutical composition . Background technique [0002] Injectable oil can be used as a liquid carrier (such as developing carrier, embolism carrier, slow-release carrier, etc.) to prepare injections for treating solid tumors. However, injection dose limitations often limit the clinical application of these injectable oils. For example, a useful dose of a grease (eg iodized oil) comprising a vegetable oil and a developing substance (eg iodine) as developer is about <25 ml. As another example, when vegetable oil is used as an embolism carrier, the embolism dose is also about <25ml. In order to obtain a more complete contrast or / and embolization effec...

Claims

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Application Information

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IPC IPC(8): A61K49/00A61K9/107A61K45/00A61K47/14A61K47/44A61P35/00
CPCA61K9/0019A61K9/107A61K45/00A61K47/14A61K47/44A61K49/006A61K49/0076A61P35/00
Inventor 邹方霖邹礼常王建霞王艺羲
Owner CHENGDU KUACHANGAOPU MEDICAL TECH CO LTD