Weightlessness simulation effect rotation device system capable of monitoring cell growth state online in real time

Abstract

The invention relates to a weightlessness simulation effect rotation device system capable of monitoring the cell growth state online in real time, which comprises a rotation device body; a cell culture container with the impedance sensitive electrode, which is used for providing a carrier for cell adherent growth and sensing impedance change in the cell culture process; and a peripheral detection and analysis module, which is used for detecting, processing and analyzing a cell impedance signal and is respectively connected with the rotary device body and the impedance sensitive electrode of the cell culture container. According to the invention, the cell growth state can be monitored in a real-time, label-free and high-sensitivity manner, and a monitoring technical guarantee is provided for objective and accurate research of a ground simulation weightless cell culture experiment; meanwhile, the invention can be used for real-time cell growth monitoring in gyrator-based cell culture industry and experimental research in the fields of biotechnology, medical diagnosis and the like.

Description

technical field [0001] The invention relates to a biological monitoring device, and mainly relates to a weightless simulating effect rotary device system capable of monitoring cell growth state on-line in real time. Background technique [0002] The gyratory device for cell weightlessness simulation effect is an important basic platform for cell culture research in a weightless environment on the ground. However, none of the existing gyratory devices for weightlessness simulation effect has the function of real-time online monitoring of cell growth status, and cannot capture the growth of cells during the gyration process. Cells change, so important hidden information can be lost. Conventional cell proliferation detection methods, such as microscope imaging, fluorescent labeling detection, flow cytometry, etc., are either difficult to achieve quantitative detection, or require special treatment of cells, or need to remove cells to terminate culture, and cannot realize the ce...

AI Technical Summary

Problems solved by technology

[0002] The gyratory device for cell weightlessness simulation effect is an important basic platform for cell culture research in a weightless environment on the ground. However, none of the existing gyratory devices for weightlessness simulation effect has the function of real-time online monitoring of cell growth status, and cannot capture the growth of cells during the gyration process. Cell changes, so important hidden information can be lost

Conventional cell proliferation detection methods, such as microscope imaging, fluorescent labeling detection, flow cytometry, etc., are either difficult to achieve quantitative detection, or require special treatment of cells, or need to take out cells to terminate culture, and cannot realize the transformation of cells in the process Growth real-time monitoring

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