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Hydrogel dressing capable of promoting wound healing

A wound healing and hydrogel technology, applied in medical science, bandages, etc., can solve the problems of not having self-adaptive properties, unable to function together, and low water content of hydrogels

Pending Publication Date: 2021-08-20
SHAANXI GIANT BIOTECHNOLOGY CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, based on at least the following reasons, the above-mentioned expectations of the researchers have not been realized: 1. No matter what method is used in the prior art to prepare polyvinyl alcohol hydrogels containing tannic acid, the gel fraction is very low, that is, A large amount of water is discharged from the system during the preparation process, resulting in low water content and hard texture of the prepared hydrogel, not to mention self-adaptive properties; 2. Tannic acid will cause the aggregation of Fan's recombinant collagen molecules Lead to precipitation, so that the two cannot effectively coexist in the polyvinyl alcohol hydrogel system, and cannot function together

Method used

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  • Hydrogel dressing capable of promoting wound healing
  • Hydrogel dressing capable of promoting wound healing
  • Hydrogel dressing capable of promoting wound healing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] 1) Weigh polyvinyl alcohol, dissolve it in deionized water and heat it to 90° C. to dissolve it completely, and prepare a 10% by weight PVA solution.

[0068] 2) Weigh borax and dissolve it in deionized water, and ultrasonically dissolve it completely to form a solution of 2.67% by weight.

[0069] 3) Weighing tannic acid and dissolving it in deionized water, ultrasonically dissolving it completely, and preparing an 8% by weight solution.

[0070] 4) Weigh human-like collagen and dissolve it in deionized water, dissolve it in a constant temperature water bath at 37° C., and prepare an 8% by weight solution.

[0071] 5) 30 parts by weight of the borax solution prepared in step 2) and 10 parts by weight of the Fan's recombinant collagen solution prepared in step 4) are mixed evenly, and then 10 parts by weight of the tannic acid solution prepared in step 3) are added to obtain Solution B, solution B was added to 50 parts by weight of the polyvinyl alcohol solution prepar...

Embodiment 2

[0073] 1) Weigh polyvinyl alcohol, dissolve it in deionized water and heat it to 90° C. to dissolve it completely, and prepare a 10% by weight PVA solution.

[0074] 2) Weigh borax and dissolve it in deionized water, and ultrasonically dissolve it completely to form a solution of 2.67% by weight.

[0075] 3) Weighing tannic acid and dissolving it in deionized water, ultrasonically dissolving it completely, and preparing a 16% by weight solution.

[0076] 4) Weigh human-like collagen and dissolve it in deionized water, dissolve it in a constant temperature water bath at 37° C., and prepare an 8% by weight solution.

[0077] 5) 50 parts by weight of step 1) the polyvinyl alcohol solution prepared and 10 parts by weight of the step 4) Fan's recombinant collagen solution prepared, mixed to obtain solution C, the borax solution prepared by 30 parts by weight of step 2) Mix evenly with 10 parts by weight of the tannic acid solution prepared in step 3) to obtain solution D, and fina...

Embodiment 3

[0079] 1) Weigh polyvinyl alcohol, dissolve it in deionized water and heat it to 90° C. to dissolve it completely, and prepare a 10% by weight PVA solution.

[0080] 2) Weigh borax and dissolve it in deionized water, and ultrasonically dissolve it completely to form a solution of 2.67% by weight.

[0081] 3) Weighing tannic acid and dissolving it in deionized water, ultrasonically dissolving it completely, and preparing a 24% by weight solution.

[0082] 4) Weigh human-like collagen and dissolve it in deionized water, dissolve it in a constant temperature water bath at 37° C., and prepare an 8% by weight solution.

[0083] 5) Get 30 parts by weight of the borax solution prepared in step 2) and 10 parts by weight of the tannic acid solution prepared in step 3) and mix evenly, then add 10 parts by weight of the Fan's recombinant collagen solution prepared in step 4) to obtain Solution A, solution A was added to 50 parts by weight of the polyvinyl alcohol solution prepared in st...

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Abstract

The invention discloses a hydrogel dressing capable of promoting wound healing. The hydrogel dressing comprises 1-15 parts by weight of polyvinyl alcohol, 0.3-10 parts by weight of tannic acid, 0.1-10 parts by weight of borax, 0.1-10 parts by weight of Fan's recombinant collagen, and the balance water (on the basis of 100 parts by weight of the hydrogel dressing), wherein the weight ratio of the borax to the tannic acid is 1: 3 or above. The invention provides the self-adaptive polyvinyl alcohol hydrogel dressing in which the Fan's recombinant collagen and the tannic acid can coexist and jointly exert functions.

Description

technical field [0001] The technology relates to the technical field of biomedical materials, in particular to a polyvinyl alcohol hydrogel dressing that can promote wound healing. Background technique [0002] Polyvinyl alcohol hydrogel is often used as a base material for wound dressings. However, wound dressings based on polyvinyl alcohol hydrogel are often morphologically fixed and not self-adaptive. They can only cover the surface of the wound and cannot be used for deep and The inside of an irregular wound. It should be noted that the self-adaptability of hydrogel materials means that this hydrogel is at the critical point of fluid and gel, and its shape can change spontaneously to adapt to external conditions, such as irregular or deep and complex wounds. [0003] Tannic acid is a weakly acidic polyphenolic compound with strong adhesion, especially to enhance cell attachment and proliferation. The high adhesion of tannic acid is attributed to the active catechol grou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/008A61L26/0014A61L26/0004A61L26/0033A61L26/0061A61L26/0066A61L2300/41A61L2300/404A61L2300/23C08L29/04
Inventor 范代娣雷桓严建亚
Owner SHAANXI GIANT BIOTECHNOLOGY CO LTD
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