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Pharmaceutical composition for treating ulcerative colitis and application thereof

A technology for ulcerative colitis and a composition, applied in the field of traditional Chinese medicine, can solve the problems of unstable drug efficacy, cure the symptoms but not the root cause, and strong drug dependence, and achieve the effects of relieving the trend of weight loss, prolonging the length of the colon, and reducing the DAI score.

Active Publication Date: 2021-08-24
FOSHAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment of Western medicine for UC is mainly for the symptoms of its attack period, usually hormone and immunosuppressant treatment, but during the period of medication, there are often problems such as unstable drug efficacy and strong drug dependence, which is a kind of palliative treatment. non-curative treatment

Method used

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  • Pharmaceutical composition for treating ulcerative colitis and application thereof
  • Pharmaceutical composition for treating ulcerative colitis and application thereof
  • Pharmaceutical composition for treating ulcerative colitis and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] This embodiment is a pharmaceutical composition for treating ulcerative colitis: it consists of the extract of feces.

[0038] The preparation method of the total alkaloid extract of feces scorpion comprises the following steps:

[0039] S1. Take 100 g of the whole herb of Dung Keep, use 8 times the volume fraction of 95% ethanol aqueous solution, reflux extraction at 90° C. for 3 times, each time for 2 hours, combine and concentrate under reduced pressure to obtain 10.5% ethanol aqueous extract of Dung. g.

Embodiment 2

[0041] This embodiment is a pharmaceutical composition for treating ulcerative colitis: it consists of extracts of total alkaloids of feces.

[0042] The preparation method of the total alkaloid extract of feces scorpion comprises the following steps:

[0043] S1. Take 100 g of the whole herb of Dung Keep, use 8 times the volume fraction of 95% ethanol aqueous solution, reflux extraction at 90° C. for 3 times, each time for 2 hours, combine and concentrate under reduced pressure to obtain 10.5% ethanol aqueous extract of Dung. g.

[0044] S2. Add the ethanol aqueous extract of feces to water, add sodium hydroxide to adjust the pH to 9, add 1 volume of chloroform for extraction, and collect the chloroform layer I and the water layer.

[0045] Take the water layer, add dilute hydrochloric acid to adjust the pH to 3, then extract with 1 volume of chloroform, collect the chloroform layer II; combine the chloroform layer I and the chloroform layer II, and concentrate under reduced...

Embodiment 3

[0047] This embodiment is a pharmaceutical composition for treating ulcerative colitis: it is composed of the total alkaloid extract of feces and gardenia extract.

[0048] The preparation method of the total alkaloid extract of feces scorpion comprises the following steps:

[0049] S1. Take 100 g of the whole herb of Dung Keep, use 8 times the volume fraction of 95% ethanol aqueous solution, reflux extraction at 90° C. for 3 times, each time for 2 hours, combine and concentrate under reduced pressure to obtain 10.5% ethanol aqueous extract of Dung. g.

[0050] S2. Add the ethanol aqueous extract of feces to water, add sodium hydroxide to adjust the pH to 9, add 1 volume of chloroform for extraction, and collect the chloroform layer I and the water layer.

[0051]Take the water layer, add dilute hydrochloric acid to adjust the pH to 3, then extract with 1 volume of chloroform, collect the chloroform layer II; combine the chloroform layer I and the chloroform layer II, and con...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating ulcerative colitis and application thereof. The pharmaceutical composition for treating ulcerative colitis is prepared from the following raw materials: a long stephania herb extract. The pharmaceutical composition for treating ulcerative colitis, disclosed by the invention, has the advantages that the weight drop trend of a mouse with DSS-induced ulcerative colitis is obviously relieved, the DAI score is reduced, the colon length is prolonged, the general colon form score is improved, the inflammation infiltration degree is relieved, and the accumulation of MPO enzyme in colon tissues is inhibited.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a pharmaceutical composition for treating ulcerative colitis and its application. Background technique [0002] Ulcerative colitis (UC) is a chronic nonspecific inflammatory disease of the rectum and colonic mucosa and submucosa. In recent years, the incidence of UC has increased year by year in newly industrialized countries such as Asia and Africa. Because of its complex etiology, long duration, recurrent symptoms, difficult to cure and may be related to the occurrence of colon cancer, it has attracted much attention. At present, the treatment of Western medicine for UC is mainly for the symptoms of its attack period, usually hormone and immunosuppressant treatment. However, problems such as unstable drug efficacy and strong drug dependence often occur during the medication period. Non-curative treatment. Clinical practice has proved that the use of traditional Ch...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/59A61K36/744A61P1/00A61P1/04
CPCA61K36/59A61K36/744A61P1/00A61P1/04A61K2236/333A61K2236/51A61K2300/00Y02A50/30
Inventor 林荣霄刘辉杨安平陈宏远
Owner FOSHAN UNIVERSITY
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