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Pharmaceutical composition comprising pibf protein as active ingredient for prevention or treatment of inflammatory disease

A technology of active ingredients and compositions, applied in the field of pharmaceutical compositions for preventing or treating inflammatory diseases containing PIBF protein as an active ingredient, can solve the problems of increased cancer, thrombosis side effects, unproven and other problems, and achieves reduction of airway. Effects of inflammation

Pending Publication Date: 2021-08-24
UNIV OF ULSAN FOUND FOR IND COOPERATION +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the treatment of certain diseases by manipulating estrogen has not been proven so far
In addition, long-term use of estrogen after menopause increases the risk of serious side effects such as cancer and blood clots, which makes it difficult to use it for the treatment of lifelong chronic diseases

Method used

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  • Pharmaceutical composition comprising pibf protein as active ingredient for prevention or treatment of inflammatory disease
  • Pharmaceutical composition comprising pibf protein as active ingredient for prevention or treatment of inflammatory disease
  • Pharmaceutical composition comprising pibf protein as active ingredient for prevention or treatment of inflammatory disease

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0069] Preparation Example 1: Preparation of Pharmaceutical Formula

[0070] 1-1. Preparation of powder

[0071] PIBF protein of the present invention 0.1g

[0072] Lactose 1.5g

[0073] Talc powder 0.5g

[0074] The above components were mixed and filled into a sealed bag to prepare a powder.

[0075] 1-2. Preparation of tablet

[0076] PIBF protein of the present invention 0.1g

[0077] Lactose 7.9g

[0078] Crystalline Cellulose 1.5g

[0079] The above-mentioned components are mixed and then subjected to a direct compression method to prepare tablets.

[0080] 1-3. Preparation of capsules

[0081] PIBF protein of the present invention 0.1g

[0082] Cornstarch 5g

[0083] Carboxylated cellulose 4.9g

[0084]The above-mentioned components are mixed to prepare a powder, and then the powder is filled into hard capsules according to a conventional method for preparing capsules to prepare capsules.

preparation Embodiment 2

[0085] Preparation Example 2: Preparation of Health Food

[0086] 2-1. Preparation of flour-based food

[0087] 0.5 to 5.0 parts by weight of the PIBF protein of the present invention are added to wheat flour and mixed. The resulting mixture is then used to prepare bread, cakes, biscuits, shortbread and noodles.

[0088] 2-2. Preparation of dairy products

[0089] 5 to 10 parts by weight of the PIBF protein of the present invention are added to milk, and the resulting milk is used to prepare various dairy products such as butter and ice cream.

[0090] Ulsan National University Industry-University Cooperation Foundation, Asan Social Welfare Foundation

[0091] Pharmaceutical composition for preventing or treating inflammatory diseases comprising PIBF protein as an active ingredient

[0092] PCT5040336

[0093] KR 10-2018-0172897

[0094] 2018-10-28

[0095] 2

[0096] KoPatentIn 3.0

[0097] 1

[0098] 1648

[0099] DNA

[0100] Artificial sequence

[01...

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Abstract

The present invention relates to a pharmaceutical composition comprising a progesterone induced blocking factor (PIBF) protein as an active ingredient for prevention or treatment of inflammatory disease. In the present invention, menopausal asthma animal models have been experimentally identified to decrease airway inflammation when treated with PIBF protein. Thus, the composition can be advantageously used in menopausal female asthma patients.

Description

technical field [0001] This application claims priority and benefit to Korean Patent Application No. 2018-0172897 filed on December 28, 2018, the disclosure of which is incorporated herein by reference in its entirety. [0002] The present invention relates to a pharmaceutical composition for preventing or treating inflammatory diseases, which comprises progesterone induction blocking factor (PIBF) protein as an active ingredient. Background technique [0003] Asthma is a relatively common chronic disease that causes chronic inflammation and airway obstruction, with a prevalence of approximately 5% in Korea. Chronic obstructive airway disease is a disease with rapidly increasing morbidity and mortality, and belongs to the "category 1 disease requiring special attention", which is included in the four categories of non-communicable diseases recently designated by WHO. [0004] Asthma is a disease known to have a wide range of disease severity and prognosis and prevalence dep...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/16A23L33/17A61K45/06A61P29/00
CPCA61P29/00A61P11/06A23L33/17A61K45/06A21D2/26A23C9/1526A23C15/12A23G9/38A23G9/36A61K38/1709A61K9/2018A61K9/2054A61K9/4866A61K9/0056A61K38/16A61K47/6811A23V2002/00A23V2200/324A23V2200/314
Inventor 赵柔淑崔埈标白寅丁权赫秀朴炤映
Owner UNIV OF ULSAN FOUND FOR IND COOPERATION
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