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Antigen peptide related to breast cancer driver gene mutation and application of antigen peptide

A driver gene, breast cancer technology, applied in the field of biomedicine, can solve the problems of superior therapeutic agents and failure to form effects, and achieve the effect of inhibiting tumor cell growth, good clinical transformation and disease prevention prospects

Active Publication Date: 2021-08-27
上海保亿仁生物医药有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, because technology requires multidisciplinary, high-tech, and multi-platform collaborative research, antigenic peptides related to breast cancer driver gene mutations have not been systematically discovered and a relatively complete peptide library has not been established, so it has not yet formed a superior effect. therapeutic agent

Method used

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  • Antigen peptide related to breast cancer driver gene mutation and application of antigen peptide

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Experimental program
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Effect test

Embodiment Construction

[0018] Below, in conjunction with specific embodiment, the present invention is described further:

[0019] Antigen peptides related to breast cancer driver gene mutations used in the examples are shown in Table 1:

[0020] Table 1 Antigenic peptide sequences associated with breast cancer driver gene mutations

[0021]

[0022] The operation for the establishment of antigen peptide-specific CTL clones related to breast cancer driver gene mutations is as follows:

[0023] 10 from the same healthy donor 5 CD8 + T cells by loading 10 antigenic peptides associated with breast cancer driver mutations 4 Mo-DCs were stimulated twice at intervals of 1 week, and then passed autologous 10 5 Mitomycin C-treated PBMCs loaded with antigenic peptides associated with breast cancer driver gene mutations were stimulated once and screened by standard cytotoxicity assays.

[0024] T2 cells were loaded with 5uM antigenic peptides associated with breast cancer driver gene mutations as targ...

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Abstract

The invention discloses an antigen peptide related to breast cancer driver gene mutation. A breast cancer driver gene is at least two of ABCB11, ESR1, GATA3, PALB2, SNX4, SLC24A4, HAUS3 and KMT2C; the sequences of the antigen peptides are at least two of SEQ No.1-18; and according to the application of the antigen peptide, the antigen peptide is used for inducing generation of specific cytotoxic T cell clone. The antigen peptide has high affinity with MHC I molecules on DC cells, can effectively stimulate and induce generation of specific cytotoxic T lymphocytes, can be used for immune clearance of breast cancer related driver gene mutation tumor cells, and has good treatment potential.

Description

technical field [0001] The invention relates to an antigenic peptide related to breast cancer driver gene mutation and application thereof, belonging to the technical field of biomedicine. Background technique [0002] Breast cancer has become a major public health problem in the current society. The etiology of breast cancer is not yet fully understood. Studies have found that there is a certain regularity in the incidence of breast cancer, and women with high-risk factors for breast cancer are prone to breast cancer. The so-called high-risk factors refer to various risk factors related to the incidence of breast cancer. [0003] The treatment of breast cancer mostly adopts various methods such as surgery, radiotherapy, chemotherapy, endocrine therapy, biological targeted therapy and traditional Chinese medicine adjuvant therapy. Surgery plays an important role in the diagnosis, staging and comprehensive treatment of breast cancer. Radiation therapy is the use of radiati...

Claims

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Application Information

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IPC IPC(8): C07K14/47C07K14/52C12N5/0783A61K39/00A61P35/00
CPCC12N5/0638A61K39/0011A61P35/00C12N2501/999C07K14/4748C07K14/523A61K39/001142C12N2501/21
Inventor 郝冰娜李许峰罗夫辛克纳吉蔡睿赵环张积仁
Owner 上海保亿仁生物医药有限公司
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