Establishment method of mouse motion model

An exercise model, a technology for establishing methods, applied in biochemical equipment and methods, microbial determination/inspection, instruments, etc., can solve the problem of less research on the liver, and achieve the effect of weight loss and promotion of activation

Inactive Publication Date: 2021-08-31
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] At present, the research on the activation of AMPK by exercise and the regulation of metabolism is mostly focused on skeletal muscle, and less research is done on the liver

Method used

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  • Establishment method of mouse motion model
  • Establishment method of mouse motion model
  • Establishment method of mouse motion model

Examples

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Embodiment Construction

[0015] The present invention will be described in further detail below in conjunction with the accompanying drawings and specific embodiments, including materials used and specific sources.

[0016] The methods in the following examples are common methods unless otherwise specified. Animals, cells, instruments, reagents, etc. used in the following examples can all be obtained from commercial sources unless otherwise specified.

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Abstract

The invention provides an establishment method of a mouse motion model, and belongs to the field of biology. According to the establishment of the motion model, by setting parameters of running exercise, the situation that a mouse reaches a certain amount of exercise is ensured, and therefore a mouse subjected to exercise training is obtained. Data show that the weight of the mouse subjected to exercise training can be reduced, phosphorylation of liver AMPK protein of the mouse can be promoted, expression of liver fat synthesis and glycogen synthesis genes is inhibited, and the effect of being beneficial to liver health is shown. The motion model may become a means for researching mouse liver metabolism or an auxiliary method for treating liver metabolism related diseases.

Description

technical field [0001] The invention belongs to the field of biology, and in particular relates to a method for establishing a mouse exercise model and its beneficial effect on liver metabolism. Background technique [0002] With the advancement of society, human beings no longer need to spend a lot of physical energy to collect food to meet their nutritional needs. In today's era, most people's daily energy intake and consumption are not balanced. Too much energy intake without proper physical activity to consume these energy is not conducive to the health of metabolism. A sedentary lifestyle is associated with a high incidence of chronic diseases and affects the body's metabolism and immunity to varying degrees. According to the statistics of the World Health Organization, lack of exercise is a high-risk factor, and the number of people who die from lack of exercise ranks fourth among all influencing factors. As a powerful measure to prevent and intervene chronic disease...

Claims

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Application Information

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IPC IPC(8): A01K67/02G01N33/573C12Q1/6851
CPCA01K67/02G01N33/573C12Q1/6851G01N2333/912C12Q2531/113C12Q2563/107C12Q2521/107C12Q2545/114
Inventor 王艳东李子柔
Owner BEIJING UNIV OF CHEM TECH
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