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Phase locked fourier transform linear ion trap mass spectrometry

A linear ion trap and mass analyzer technology, applied in the field of systems used in Fourier transform mass spectrometers, can solve problems such as low average signal intensity, loss of ion micro-motion information, etc.

Pending Publication Date: 2021-09-10
DH TECH DEVMENT PTE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] However, the time at which ions can be preferentially ejected from the ion trap by MSAE can vary from scan to scan, resulting in lower average signal intensities and due to fringing fields near the output of the ion trap converting their radial motion to axial Loss of information about ion micromobility due to directional motion

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  • Phase locked fourier transform linear ion trap mass spectrometry
  • Phase locked fourier transform linear ion trap mass spectrometry
  • Phase locked fourier transform linear ion trap mass spectrometry

Examples

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example 1

[0104] Sciex sells 4000 on the market mass spectrometer (similar to Figure 9The mass spectrometer shown) was modified according to the present teachings. A waveform generator (Keysight 33520B waveform generator) was used to generate a mass analysis quadrupole (e.g. Figure 9 The clock signal of the driving radio frequency of the quadrupole device Q3). The waveform generator triggers at the beginning of the sweep function and adjusts the number of cycles so that the signal ends at the falling / reset portion of the sweep, which lasts approximately the last 100 microseconds of the sweep function. The second channel and sync output of the waveform generator are also set to generate the signal and delay with respect to the trigger ground. Specifically, ion excitation and data acquisition were triggered approximately 10.25 ms after the waveform generator trigger. In this way, RF drive, excitation and detection are all phase locked at the beginning of the mass analysis section. ...

example 2

[0109] Figure 12 Transmission-mode FT-LIT transients of reserpine with (gray trace) and without (black trace) phase locking are shown, Figure 13 The corresponding mass spectra are depicted. The same mass spectrometer as used in the previous example was used, except for the reduced kinetic energy of the ions in the mass-analyzing quadrupole setup, resulting in higher-resolution micromotion information. Similar to the previous example, when the drive RF, excitation, and detection signals are phase locked, the signal amplitude increases because the timing associated with ion preferential ejection is substantially the same from one scan to the next.

[0110] This data demonstrates that ion micromotions are visible in the phase-locked transient and further demonstrates that the amplitude of the mass signal corresponding to the phase-locked transient is larger than that of the non-phase-locked transient The amplitude of the corresponding mass signal.

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Abstract

In one aspect, a mass analyzer is disclosed, which comprises a quadrupole having an input end for receiving ions and an output end through which ions can exit the quadrupole, said quadrupole having a plurality of rods to at least some of which a drive RF signal and an excitation signal can be applied. A fixed phase relationship is maintained between the drive RF signal and the excitation signal, thereby enhancing the signal-to-noise ratio of the mass detection signal.

Description

[0001] related application [0002] This application claims priority to U.S. Provisional Application No. 62 / 800,383, entitled "Phase-Locked Fourier Transform Linear Ion Trap Mass Spectrometry," filed February 1, 2019, which is incorporated herein by reference in its entirety . technical field [0003] The present invention relates generally to systems and methods for mass spectrometry and, in particular, to systems and methods that can be used in Fourier transform mass spectrometers. Background technique [0004] Mass spectrometry (MS) is an analytical technique used to determine the elemental composition of a test substance and has both quantitative and qualitative applications. For example, mass spectrometry can be used to identify unknown compounds, determine the isotopic composition of elements in molecules, determine the structure of a specific compound by looking at its fragments, and quantify the amount of a specific compound in a sample. [0005] In some mass spec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/38H01J49/42
CPCH01J49/38H01J49/422
Inventor E·T·德泽科斯基
Owner DH TECH DEVMENT PTE