Preparation method of pharmaceutical composition for treating gout and gouty arthritis

A technology for gouty arthritis and compositions, which is applied in the field of preparation of pharmaceutical compositions, can solve problems such as precipitation and turbidity of medicinal liquid, and achieve the effect of avoiding precipitation and rapid decline

Active Publication Date: 2021-09-17
SICHUAN SUNNYHOPE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The object of the present invention is to provide a preparation method of a pharmaceutical composition for the treatment of gout and gouty arthritis, so as to solve the problem of floating oil in the liquid medicine, turbidity of the liquid medicine after sterilization and prolonged storage in the Binhuofeng mixture prepared by the existing preparation process. The technical problem of precipitation in the latter drug solution

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  • Preparation method of pharmaceutical composition for treating gout and gouty arthritis

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Experimental program
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Effect test

Embodiment 1

[0032] A preparation method of a pharmaceutical composition for the treatment of gout and gouty arthritis, comprising the steps of:

[0033] (1) extraction

[0034] Weigh the effective raw materials according to the prescription: betel nut 320g, epimedium 220g, evodia 30g, silkworm excrement 200g, perilla leaf 80g, turmeric 80g, bellflower 60g, tangerine peel 80g, ginger 100g, coix seed 150g, atractylodes 100g, papaya 80g;

[0035] Add water 5 times the total weight of the effective raw material to the medicinal raw material and boil for reflux extraction, collect 450ml of the refluxed aromatic water as standby medicinal liquid A, perform solid-liquid separation after the reflux extraction is completed, and obtain primary extract and medicinal residue; Continue adding water to the slag for 2 decoctions, the amount of water added for each decoction is 8 times the total weight of the medicinal raw materials, and the filtrate after each decoction is collected and mixed with the p...

Embodiment 2

[0046] A preparation method of a pharmaceutical composition for the treatment of gout and gouty arthritis, comprising the steps of:

[0047] (1) extraction

[0048] Weigh the effective raw materials according to the prescription: betel nut 320g, epimedium 220g, evodia 30g, silkworm excrement 200g, perilla leaf 80g, turmeric 80g, bellflower 60g, tangerine peel 80g, ginger 100g, coix seed 150g, atractylodes 100g, papaya 80g;

[0049]Add water 6 times the total weight of the effective raw material to the medicinal raw material and boil for reflux extraction, collect 500ml of the refluxed aromatic water as standby medicinal liquid A, perform solid-liquid separation after the reflux extraction is completed, and obtain primary extract and medicinal residue; Continue to add water to the slag and decoct 3 times, the amount of water added for each decoction is 7 times the total weight of the medicinal raw materials, collect the filtrate after each decoction and mix it with the primary ...

Embodiment 3

[0060] A preparation method of a pharmaceutical composition for the treatment of gout and gouty arthritis, comprising the steps of:

[0061] (1) extraction

[0062] Weigh the effective raw materials according to the prescription: betel nut 320g, epimedium 220g, evodia 30g, silkworm excrement 200g, perilla leaf 80g, turmeric 80g, bellflower 60g, tangerine peel 80g, ginger 100g, coix seed 150g, atractylodes 100g, papaya 80g;

[0063] Add water 4 times the total weight of the effective raw material to the medicinal raw material and boil for reflux extraction, collect 400ml of the refluxed aromatic water as standby medicinal liquid A, perform solid-liquid separation after the reflux extraction is completed, and obtain primary extract and medicinal residue; Continue to add water to the slag for 4 decoctions, the amount of water added for each decoction is 6 times the total weight of the medicinal raw materials, collect the filtrate after each decoction and mix it with the primary e...

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Abstract

The invention discloses a preparation method of a pharmaceutical composition for treating gout and gouty arthritis, and solves the technical problems of floating oil in liquid medicine, turbid liquid medicine after sterilization and precipitation of the liquid medicine after long-term storage in a Bin Huo Tong Feng He Ji (a traditional Chinese medicinal mixture) prepared by an existing preparation process. The method comprises the following steps of (1) extracting, (2) precipitating with alcohol, (3) precipitating with water, adding glycerol, Tween 80, sorbic acid, citric acid and purified water, uniformly stirring, adjusting the pH value to 5.3-5.5, then slightly boiling, supplementing water, adjusting the pH value to 5.3-5.5, refrigerating and filtering in sequence; and (4) preparing liquid and sterilizing to obtain a finished product of the pharmaceutical composition for treating gout and gouty arthritis. According to the preparation method of the pharmaceutical composition for treating gout and gouty arthritis, the problem of oil floating of liquid medicine is solved, the precipitation phenomena of clouding formation and the like after a traditional Tween-containing traditional Chinese medicine oral preparation is sterilized are avoided, and the phenomenon of precipitation caused by long-time storage of a liquid medicine finished product is also avoided.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine compositions, in particular to a preparation method of a medicinal composition for treating gout and gouty arthritis. Background technique [0002] Binghuo Fengfeng Mixture is an exclusive product of Sichuan Shenghe Pharmaceutical Co., Ltd. It has the effects of dehumidification, dredging collaterals, and pain relief. It is used to relieve swelling and pain of toe-metatarsal joints caused by gout caused by damp-turbidity blockage. It is often used to treat gout And gouty arthritis, the main preparation process includes decoction and extraction of medicinal materials, alcohol precipitation, water precipitation, liquid preparation, sterilization and other steps. [0003] The applicant finds that the prior art has at least the following technical problems: [0004] 1. In the existing process, the water sedimentation filtrate is mixed with aromatic water with volatile oil, and then added T...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K47/26A61K47/10A61K47/12A61P19/06A61P19/02A61K35/64
CPCA61K36/889A61K36/296A61K36/754A61K35/64A61K36/535A61K36/9066A61K36/346A61K36/752A61K36/9068A61K36/8994A61K36/284A61K36/732A61K47/26A61K47/10A61K47/12A61P19/06A61P19/02A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 蒲虹橙杨强姚欣
Owner SICHUAN SUNNYHOPE PHARM CO LTD
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