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Cascaded m-FBG multi-biological component sensing system and multi-biological component rapid detection method

A sensing system and biological technology, which is applied in the direction of analyzing materials through chemical reactions, analyzing materials through observing the influence of chemical indicators, measuring devices, etc., to achieve the effects of short time consumption, high sensitivity and simple operation

Pending Publication Date: 2021-10-15
南京品傲光电科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Combining the micro-nano optical fiber and the problems existing in the detection of bacteria in the background technology, the present invention proposes a multi-biological component sensing system ba

Method used

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  • Cascaded m-FBG multi-biological component sensing system and multi-biological component rapid detection method
  • Cascaded m-FBG multi-biological component sensing system and multi-biological component rapid detection method
  • Cascaded m-FBG multi-biological component sensing system and multi-biological component rapid detection method

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0045] Example 1

[0046] like Figure 1-2 As shown, the cascaded M-FBG multi-biological component sensing system provided in this embodiment is mainly composed of micro-optical fiber Bragg grating array sensing unit 1 and micro-groove unit 2:

[0047] The micro-optical fiber Bragg array sensing unit 1 is mainly composed of a light source 101, a detector 106, and a transmission fiber 102 provided between the two, and the transmission fiber 102 is provided with a tapered region 103, and the pulling cone region 103 is provided with M- The FBG array 104, the outer surface of the M-FBG array 104 is provided with a variety of different biological components modified antibody 105.

[0048] Specifically, such as figure 1 As shown, the micro-fibrous Bragg grating array sensing unit 1 is composed of a light source 101, a transmitting optical fiber 102, a pulling substrate 103, a M-FBG array 104, a modified antibody 105, and a detector 106.

[0049] The light source 101 is a non-infrared bro...

Example Embodiment

[0075] Example 2

[0076] The method of rapidly detecting a multi-biological component using the cascaded M-FBG multi-biological component sensing system in Example 1, including the step of: fluid containing the bacteria to be detected by the micro-groove unit 2 from the micro-grooved groove 2011 The microfluidic inlet 202 flows into the detection groove 204 through the guide grooves I 203, and the micro-fiber Bragg array sensing unit 1 is placed in the detection groove 204, and when the bacteria flows through the detection slot 204, bacteria and M-FBG 104 The antibody on the upper antibody is bonded, causing the drift of the transmit spectrum (reflection spectrum) in the microelectric fiber Bragg array sensing unit 1, such as image 3 Indicated.

[0077] In this embodiment, the antibody that needs to be detected is modified to different grating regions, respectively, and a transmitted peak can achieve a detection of an antigen. The antibody is modified in the grating area as a con...

Example Embodiment

[0078] Example 3

[0079] The method of rapidly detecting a multi-biological component using the cascaded M-FBG multi-biological component sensing system in Example 1, including the following steps: the microfluidic body containing the cancer embryo antibody to be detected from micro-groove unit 2 from micro The microfluidic inlet 202 of the disc 2011 flows into the detection groove 204 through the guide grooves I 203, and the micro-fiber Bragg array sensing unit 1 is placed in the detection groove 204, and when the cancer embryo antibody flows through the detection slot 204, cancer The antibody in the m-FBG 104 is bonded to the m-FBG 104, causing the drift of the transmit spectrum (reflective spectrum) in the microelectric fiber Bragg array sensing unit 1.

[0080] This embodiment utilizes the cascaded M-FBG multi-biological component sensing system, while detecting a few of the carcinoembryonic antigen CEA, methylene protein AFP, cancer antigen Ca19-9, a sugar antigen CA242, tiss...

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Abstract

The invention discloses a cascaded m-FBG multi-biological component sensing system which is mainly composed of a micro-fiber bragg grating array sensing unit and a micro-flow groove unit, and the micro-fiber bragg grating array sensing unit is mainly composed of a light source, a transmission fiber, a tapering area, an m-FBG array, a modified antibody and a detector. The micro-flow groove unit mainly comprises a micro-flow groove, a cover plate, a flow guide groove I, a flow guide groove II, a detection groove, a micro-flow inlet, a micro-flow outlet, an optical fiber inlet and an optical fiber outlet, and the m-FBG array is arranged in the detection groove; the invention also discloses a multi-biological component rapid detection method by using the system, the system and the method can solve the problem of simultaneously and rapidly detecting multiple bacteria, and the system and the method have the advantages of simplicity in operation, short time consumption, no label, high sensitivity and the like.

Description

Technical field [0001] The present invention belongs to the field of fiber optic sensing, and more particularly to a cascaded M-FBG multi-biological component sensing system and a rapid detection method of multi-biological components. Background technique [0002] At present, the fiber-based biological sensing is basically only a single target. Such sensors will be limited in clinical applications, in particular to quickly detect multiple targets. For example, respiratory bacterial infection involves a variety of bacteria, such as Bowman, Copper Green Pseudomonas, Pneumoniae, Bacillus, Escherichia coli, Golden Staphylococcus, Enterococci, Swinus and White Candida, etc. . Quickly detecting a variety of bacteria can provide accurate and effective basis for diagnosis, and also won more time for the patient's follow-up treatment, which has extremely important for patients and their families. [0003] The traditional fiber Bragg Grating, FBG is not sensitive to the external refractive...

Claims

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Application Information

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IPC IPC(8): G01N21/77G01N21/359
CPCG01N21/7743G01N21/359
Inventor 刘伟平叶晓平郭戈伟高社成黄新成
Owner 南京品傲光电科技有限公司
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