Use of 1-ethyl-3, 7-dimethylxanthine in preparing medicine for treating pneumonia

A pneumonia and drug technology, applied in the field of medicine, can solve problems such as changing the clinical symptoms of pneumonia, reducing mortality, and rapidly improving inflammatory responses

Active Publication Date: 2021-10-26
WEST CHINA HOSPITAL SICHUAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, antimicrobial treatment alone cannot significantly and quickly improve the inflammatory response, but inhibiting the production of pro-inflammatory cytokines can change the clinical symptoms of pneumonia and reduce mortality

Method used

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  • Use of 1-ethyl-3, 7-dimethylxanthine in preparing medicine for treating pneumonia
  • Use of 1-ethyl-3, 7-dimethylxanthine in preparing medicine for treating pneumonia
  • Use of 1-ethyl-3, 7-dimethylxanthine in preparing medicine for treating pneumonia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation of embodiment 1 common tablet of the present invention

[0035] Mix CF crystals with about 1 / 3 of the starch, add starch slurry and mix to make a soft material, granulate with a 16-mesh sieve, dry at 60°C, pass the dry granules through a 14-mesh sieve for granulation, add the remaining starch (in advance at 100 Dry at -105°C) and microcrystalline cellulose, pass through a 14-mesh sieve, and press into tablets to obtain.

Embodiment 2

[0036] Embodiment 2 Preparation of injection of the present invention

[0037] Add CF powder into pure water to make a concentration of 5 mg / mL, filter and sterilize with a 0.22 μm disposable membrane filter, and pack it into a sterilized ampoule for use.

Embodiment 3

[0038] The preparation of embodiment 3 sprays of the present invention

[0039] CF powder is dissolved in pure water, and xylitol and ethyl maltol are added as flavoring agents.

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Abstract

The invention relates to use of 1-ethyl-3, 7-dimethylxanthine in preparing a medicine for treating pneumonia and belongs to the technical field of medicines. The invention provides use of 1-ethyl-3, 7-dimethylxanthine or a salt thereof in preparing a medicine for treating pneumonia. Pharmacological experiment results show that various dosage forms of the 1-ethyl-3, 7-dimethylxanthine can obviously inhibit pneumonia caused by infection of viruses, bacteria and mycoplasmas, reduce a lung index of infected mice, reduce levels of inflammatory factors such as TNF-alpha, IL-8, IL-10 and IL-17, improve a level of IFN-gamma and improve count of leukocyte and neutrophile granulocyte in peripheral blood, which indicate that the 1-ethyl-3, 7-dimethylxanthine has a strong anti-pneumonia effect.

Description

technical field [0001] The invention relates to the application of 1-ethyl-3,7-dimethylxanthine in the preparation of medicines for treating pneumonia, and belongs to the technical field of medicine. Background technique [0002] Pneumonia is an important disease that threatens human health, with high morbidity and mortality. Viral, bacterial, and mycoplasma infections are the main causes of pneumonia. For example, Mycoplasma pneumoniae is a pathogen between bacteria and viruses, and Mycoplasma pneumoniae pneumonia is lung inflammation caused by Mycoplasma pneumoniae, which is a common acquired pneumonia. Immune injury is an important pathogenesis of mycoplasma infection. Pneumonia caused by Mycoplasma pneumoniae can also cause various extrapulmonary complications, such as encephalitis, myocarditis, hepatitis and blood system diseases, which cause great harm to the human body. [0003] Studies have shown that microbial toxins can induce the combination of cytokines and in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/708A61P11/00A61P31/16A61P31/14A61P31/04A61P31/12
CPCA61K31/708A61P11/00A61P31/16A61P31/14A61P31/04A61P31/12Y02A50/30
Inventor 黄文张伯礼李幼平张俊华
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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