Liposome nanoparticles with low energy and thermal stability, and preparation method and application thereof

A liposome and thermally stable technology, applied in the field of nanoparticles, can solve the problems of poor thermodynamic stability, poor sustained release effect, weak transdermal penetration ability, etc. Effect

Inactive Publication Date: 2021-11-09
JIANGXI SCI & TECH NORMAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] However, in the prior art, liposomal nanoparticles prepared from naringenin have poor thermodynamic stability at higher temperatures, such as higher than 40°C, and also have poor slow-release effect and weak transdermal penetration ability during ap

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  • Liposome nanoparticles with low energy and thermal stability, and preparation method and application thereof
  • Liposome nanoparticles with low energy and thermal stability, and preparation method and application thereof
  • Liposome nanoparticles with low energy and thermal stability, and preparation method and application thereof

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preparation example Construction

[0029] The present invention provides a kind of preparation method of the liposomal nanoparticle of low-energy thermal stability, comprises the following steps:

[0030] (1) The surfactant is mixed with the liposome drug solution to obtain the first mixed solution;

[0031] (2) dissolving lecithin in an ethanol solution to obtain a lecithin mixture;

[0032] (3) Mix the first mixed solution obtained in step (1) with the lecithin mixed solution obtained in step (2) to obtain the second mixed solution, add the second mixed solution to water drop by drop, and stir until there is no stratification to obtain the second mixed solution. Three mixtures;

[0033] (4) Purify the third mixed solution obtained in step (3), then perform centrifugation, and finally collect the substrate to obtain low-energy heat-stable liposome nanoparticles.

[0034] In the present invention, the liposome drug solution in the step (1) is preferably a naringenin solution obtained by dimethyl sulfoxide sol...

Embodiment 1

[0046] Preparation of low-energy heat-stable naringenin nanoparticles:

[0047] (1) Fully mix a certain amount of naringenin and dimethyl sulfoxide to obtain a naringenin mixture with a concentration of 10mg / mL, and accurately weigh a certain amount of polyethylene glycol and naringenin with a molecular weight of 300-4000kDa The vegetable mixed solution is fully mixed, wherein the mass ratio of polyethylene glycol to naringenin is 3:4 to obtain the first mixed solution.

[0048] (2) A certain amount of lecithin was dissolved in 75% ethanol solution, and then stirred with a constant temperature magnetic stirrer, so that the system was fully mixed to obtain a lecithin mixture with a concentration of 20 mg / mL.

[0049] (3) With the mass ratio of naringenin and lecithin being 1:1.25, the first mixed solution obtained in step (1) and the lecithin mixed solution are fully mixed to obtain the second mixed solution, which is added dropwise to the following In water stirred at a speed...

Embodiment 2

[0053] Preparation of low-energy heat-stable hyaluronic acid nanoparticles:

[0054] (1) Fully mix a certain amount of hyaluronic acid and polybutylene succinate to obtain a hyaluronic acid mixed solution with a concentration of 15 mg / mL. Accurately weigh a certain amount of polyethylene glycol with a molecular weight of 300kDa and a mixed solution of hyaluronic acid, and mix thoroughly, wherein the mass ratio of polyethylene glycol and hyaluronic acid is 1:4 to obtain the first mixed solution.

[0055] (2) A certain amount of lecithin was dissolved in 75% ethanol solution, and then stirred with a constant temperature magnetic stirrer, so that the system was fully mixed, and the obtained concentration was 50 mg / mL lecithin mixture.

[0056] (3) With the mass ratio of hyaluronic acid and lecithin as 1:1.25, the first mixed solution obtained in step (1) and the lecithin mixed solution are fully mixed to obtain the second mixed solution, which is added dropwise to the following ...

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Abstract

The invention belongs to the technical field of nanoparticles, and discloses a preparation method of liposome nanoparticles with low energy and thermal stability; a liposome drug naringenin or hyaluronic acid is wrapped in a lecithin-loaded surfactant solution to form nano liposome drug-wrapped nanoparticles; and the stability of the liposome nanoparticles is improved. The liposome nanoparticles provided by the invention have good effects of continuous slow release and percutaneous penetration; the residence time of acting on a skin part is prolonged; the bioavailability of a liposome medicine is improved; the form and the particle size of the liposome nanoparticles are not obviously changed after the liposome nanoparticles are kept for 30 days at 40 DEG C; the form and the particle size of the liposome nanoparticles are not obviously changed after the liposome nanoparticles are kept for 15 days at 50 DEG C; and the stability of the liposome nanoparticles is good. The invention also provides application of the liposome nanoparticles in preparation of cosmetics and medicines; and the method has important significance in development of the liposome nanoparticles with good slow release effect, thermodynamic stability and good percutaneous penetration effect.

Description

technical field [0001] The invention relates to the technical field of nanoparticles, in particular to a low-energy heat-stable liposome nanoparticle and its preparation method and application. Background technique [0002] In the past 20 years, the research on nanoemulsion has developed by leaps and bounds. As a carrier, nanoemulsion has the following advantages: good stability and good permeability. As an alternative to unstable traditional emulsions and vesicles. These advantages make nanoemulsions widely used in fields such as beauty industry, agriculture, chemical industry, and pharmacy. The self-assembly of nanoemulsions is characterized by the reduction of free energy and low surface tension in the system. The application of nanoemulsions in personal skin care products and cosmetics is mainly to increase the solubility of poorly soluble active substances. Emulsions can be classified according to particle size: Traditional emulsions: particle size ranges from 100nm...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K9/127A61K47/24A61K47/36A61K47/10A61K31/352A61K31/728A61P17/02A61K8/49A61K8/73A61K8/55A61K8/14A61K8/02A61Q19/00
CPCA61K9/1652A61K9/1617A61K9/1641A61K9/127A61K9/1277A61K9/0014A61K47/24A61K47/36A61K47/10A61K31/352A61K31/728A61P17/02A61K8/498A61K8/735A61K8/553A61K8/14A61K8/025A61Q19/00A61K2800/412A61K2800/805A61K2800/10
Inventor 陈雯
Owner JIANGXI SCI & TECH NORMAL UNIV
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