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Antibacterial and tumor proliferation inhibiting degradable magnesium alloy bone nail and preparation method thereof

A magnesium alloy, anti-tumor technology, applied in the direction of additive manufacturing, additive processing, internal bone synthesis, etc., can solve the problems of not considering biological functional requirements, complicated preparation process, etc., and achieve the effect of satisfying surface accuracy and mechanical properties

Active Publication Date: 2021-11-09
西安谢赫特曼诺奖新材料研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its preparation process is relatively complicated, and it needs to be machined to achieve the structural requirements, and some biological functional requirements are not considered.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0033] The present invention also provides a method for preparing an antibacterial and anti-tumor proliferation degradable magnesium alloy bone nail, comprising the following steps:

[0034] Step 1, using a grinding wheel and sandpaper to polish the scale and impurities on the surface of the raw material to obtain a pure raw material block;

[0035] The raw materials used are commercial pure magnesium ingots with a mass fraction of not less than 99.99%, pure silver particles, Mg-30%La master alloy ingots and Mg-20%Ca master alloy ingots;

[0036] Step 2, weigh raw materials

[0037] Weigh each raw material in step 1, divide the commercial pure magnesium ingot into two parts, and one part of the commercial pure magnesium ingot is used to wrap the pure silver ingot particles in it, so as to prevent the pure silver ingot particles from falling during the smelting process and cause insufficient melting of the silver particles, resulting in Alloy composition is uneven;

[0038] I...

Embodiment 1

[0052] Step 1. Remove the scale and impurities on the surface of raw materials:

[0053] Use grinding wheels and sandpaper to grind the scale and impurities on the surface of raw materials to obtain pure raw material blocks;

[0054] Step 2, weighing raw materials:

[0055] Weigh raw materials according to the following weight ratio: pure silver particles: Mg-30% La master alloy ingot: Mg-20% Ca master alloy ingot: commercial pure magnesium ingot = 1:333:100:9566; commercial pure magnesium The ingot is divided into two parts, one part of commercial pure magnesium ingot (the quality of this part of commercial pure magnesium ingot is 10% of all commercial pure magnesium ingot) is used to wrap the pure silver ingot particles in it, and the commercial pure magnesium ingot wrapped with pure silver ingot is required The size of the hole is determined according to the size of the silver ingot. It is required to put the pure silver ingot into the hole of the pure magnesium ingot, and...

Embodiment 2

[0063] Step 1. Remove the scale and impurities on the surface of raw materials:

[0064] Use grinding wheels and sandpaper to grind the scale and impurities on the surface of raw materials to obtain pure raw material blocks;

[0065] Step 2, weighing raw materials:

[0066] Weigh raw materials according to the following weight ratio: pure silver particles: Mg-30% La master alloy ingot: Mg-20% Ca master alloy ingot: commercial pure magnesium ingot = 1:500:200:9299; The ingot is divided into two parts, one part of commercial pure magnesium ingot (the quality of this part of commercial pure magnesium ingot is 10% of all commercial pure magnesium ingot) is used to wrap the pure silver ingot particles in it, and the commercial pure magnesium ingot wrapped with pure silver ingot is required The size of the hole is determined according to the size of the silver ingot. It is required to put the pure silver ingot into the hole of the pure magnesium ingot, and it is advisable to cover ...

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PUM

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Abstract

The invention discloses an antibacterial and tumor proliferation inhibiting degradable magnesium alloy bone nail. The degradable magnesium alloy bone nail comprises the following components of, in percentage by weight, 0.01-0.05% of Ag, 1-2% of La, 0.2-0.4% of Ca and the balance of magnesium, and the sum of the weight percentages of the components is 100%. The alloy bone nail not only has excellent biocompatibility, but also has the functions of long-acting antibiosis and tumor proliferation inhibition. The invention further provides a preparation method of the degradable magnesium alloy bone nail.

Description

technical field [0001] The invention belongs to the technical field of degradable medical metal materials, and in particular relates to a degradable magnesium alloy bone nail which is antibacterial and inhibits tumor growth, and also relates to a preparation method of a degradable magnesium alloy bone nail which is antibacterial and inhibits tumor growth. Background technique [0002] Magnesium alloy is one of the lightest structural materials and is known to have high biocompatibility, excellent specific strength and specific stiffness. The density of pure magnesium is 1.74g / cm 3 About, and human bone density (1.75g / cm 3 ) is equivalent, the Young's modulus of magnesium alloy is about 45GPa, which is the bio-friendly metal material closest to the elastic modulus (20GPa) of human bone among metal structural materials. At the same time, magnesium is an essential nutrient element for the human body, most of which exist in bones, teeth and soft tissues. Magnesium is also an e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C23/06B22F5/00B22F10/28B33Y10/00B33Y70/00B33Y80/00A61B17/86
CPCC22C23/06B22F10/28B22F5/00B33Y10/00B33Y70/00B33Y80/00A61B17/86Y02P10/25
Inventor 徐春杰华心雨杨怡萨娜·扎珐李诊娇田颖晨李怡春史妍李梦阳武向权张忠明
Owner 西安谢赫特曼诺奖新材料研究院有限公司
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