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Magnesium alloy bone splint doped with hydroxyapatite and capable of inhibiting tumour proliferation and preparation method of magnesium alloy bone splint

A hydroxyapatite and magnesium alloy technology, which is applied in the directions of additive manufacturing, additive processing, and process efficiency improvement, can solve problems such as not considering functional requirements, and achieves inhibition of tumor proliferation, promotion of repair, and satisfaction of surface accuracy. and mechanical properties

Inactive Publication Date: 2021-11-09
XIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The patent "A Preparation Method of Magnesium-Based Composite Bone Implant and Its Products" (Application No.: 201811389545.0, Publication No.: CN109364292A, Publication Date: 2019.02.22) uses a three-dimensional jet printing process to form a magnesium-based composite bone implant. Implants, which can meet individual needs, but do not take into account some functional needs

Method used

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  • Magnesium alloy bone splint doped with hydroxyapatite and capable of inhibiting tumour proliferation and preparation method of magnesium alloy bone splint

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preparation example Construction

[0027] The present invention also provides a preparation method of a magnesium alloy bone splint doped with hydroxyapatite and inhibiting tumor growth, such as figure 1 shown, including the following steps:

[0028] Step 1, weighing:

[0029] Raw materials are weighed according to the following weight percentages: La powder: 2-3%, hydroxyapatite powder: 3-12%, the balance is atomized magnesium powder, and the sum of the weight percentages of the above components is 100%;

[0030] Step 2, ball milling and mixing:

[0031] Place the weighed raw material powder in a horizontal high-energy ball mill for ball milling to promote the thorough mixing of hydroxyapatite with atomized magnesium powder and La powder;

[0032] In step 2, ball milling process parameters: ball to material weight ratio 1:1, rotating speed 100-200r / min, ball milling time 8-12h, rest 10min at intervals of 1h and alternate forward and reverse rotation to ensure that the temperature of the tank will not be too ...

Embodiment 1

[0038] Step 1. Weighing:

[0039] Weigh the raw materials according to the following weight percentages: La powder: 2%, hydroxyapatite powder: 3%, the balance is atomized magnesium powder, and the sum of the weight percentages of the above components is 100%;

[0040] Step 2, ball milling and mixing:

[0041] Put the weighed powder in a horizontal high-energy ball mill for ball milling and mixing. Ball milling process parameters: ball to material weight ratio 1:1, speed 100r / min, ball milling time 10h, rest 10min at intervals of 1h and alternate forward and reverse rotation to ensure the tank The temperature will not be too high. The grinding tank is filled with argon to protect the powder from oxidation. The grinding balls used are: boron carbide grinding balls with a diameter of Φ5mm and Φ10mm, and the weight ratio of large and small balls is 1:1;

[0042] Step 3. Selected area laser melting forming:

[0043] Put the prepared magnesium alloy powder into the selective las...

Embodiment 2

[0046] Step 1. Weighing:

[0047] Weigh the raw materials according to the following weight percentages: La powder: 2.5%, hydroxyapatite powder: 12%, the balance is atomized magnesium powder, and the sum of the weight percentages of the above components is 100%;

[0048] Step 2, ball milling and mixing:

[0049] Put the weighed powder in a horizontal high-energy ball mill for ball milling and mixing. Ball milling process parameters: ball to material weight ratio 1:1, speed 150r / min, ball milling time 8h, rest 10min at intervals of 1h and alternate forward and reverse rotation to ensure that the tank The temperature will not be too high. The grinding tank is filled with argon to protect the powder from oxidation. The grinding balls used are: boron carbide grinding balls with a diameter of Φ5mm and Φ10mm, and the weight ratio of large and small balls is 1:1;

[0050] Step 3. Selected area laser melting forming:

[0051] Put the prepared magnesium alloy powder into the select...

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Abstract

The invention discloses a magnesium alloy bone splint doped with hydroxyapatite and capable of inhibiting tumour proliferation, which comprises the following components in percentage by weight: 2-3% of La, 3-12% of hydroxyapatite and the balance of magnesium, and the sum of the weight percentages of the components is 100%. The alloy not only has excellent biocompatibility, but also has the function of inhibiting tumour proliferation. The invention further discloses a preparation method of the magnesium alloy bone splint doped with hydroxyapatite and capable of inhibiting tumour proliferation. A bone splint structure with any complex shape can be prepared by using a selective laser melting technology; the complex structure requirement of the bone splint can be met; and meanwhile, the requirements of surface precision and mechanical properties can also be met.

Description

technical field [0001] The invention belongs to the technical field of degradable medical metal materials, in particular to a magnesium alloy bone splint doped with hydroxyapatite and inhibiting tumor growth, and also to a magnesium alloy bone splint doped with hydroxyapatite and inhibiting tumor growth method of preparation. Background technique [0002] The density of magnesium is 1.74g / cm 3 , is the smallest density among all metal structural materials, and is close to the density of human bone. Magnesium is an essential nutrient element for the human body, and its content in the human body is second only to Ca, Na, and K. Studies have shown that as a bone fixation material, magnesium alloys are more compatible with the mechanical properties of human bones. They can provide stable mechanical properties in the early stage of fracture healing, avoid stress shielding effects, accelerate fracture healing and shaping, and prevent local osteoporosis and fractures. In particu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/02A61L31/16C22C23/00C22C32/00C22C1/05B22F10/28B33Y70/10B33Y10/00
CPCA61L31/022A61L31/16C22C23/00C22C32/0089C22C1/05B22F10/28B33Y70/10B33Y10/00A61L2300/102A61L2300/112A61L2300/416A61L2300/412Y02P10/25
Inventor 徐春杰华心雨王银玉萨娜·扎珐史妍李梦阳杜薇李诊娇田颖晨武向权张忠明
Owner XIAN UNIV OF TECH
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