Double-sided heterogeneous degradable metal film and preparation method thereof

Abstract

The invention belongs to the technical field of medical instruments, and particularly relates to a double-sided heterogeneous degradable metal film and a preparation method thereof. The double-sided heterogeneous degradable metal film comprises a degradable metal matrix, a first film layer and a second film layer, the first film layer and the second film layer are arranged on the opposite surfaces of the metal matrix, the first film layer is a calcium phosphate coating and is arranged on the first surface of the metal matrix, and the second film layer is a calcium phosphate coating and is arranged on the second surface of the metal matrix, the second film layer is a polymeric film layer and is arranged on the second surface of the metal matrix, and the polymeric film layer has the functions of selectively promoting adhesion, migration and differentiation of bone cells and bone regeneration. The double-sided heterogeneous degradable metal film can simultaneously meet the two functional requirements of resisting bacteria and promoting bone cell regeneration, and the functional requirements of anisotropy of the two sides of the barrier film are met.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to a double-sided heterogeneous degradable metal film and a preparation method thereof. Background technique [0002] Periodontitis is one of the most prevalent and destructive diseases of the oral cavity, and severe periodontitis can lead to alveolar bone atrophy. Clinically, guided bone regeneration is one of the main ways to treat alveolar bone defects, and the key technology is the biological barrier membrane. The bio-barrier film ensures that during the repair process of the defect wound, it prevents the early entry of epithelial tissue or fibrous connective tissue into the wound to interfere with the healing process, protects key regenerative tissue components such as periodontal ligament and alveolar bone, and facilitates their preferential growth. [0003] Existing biological barrier films are divided into two categories: non-degradable barrier films (ta...

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Problems solved by technology

The published patent CN108159506A provides a magnesium alloy-guided tissue regeneration membrane and its preparation method, which solves the problems of the support of the degradable biological barrier membrane and the rapid degradation of the magnesium alloy, but it does not have a strong antibacterial effect, and there may be wound bacteria Risk of infection; the published patent CN106492271A provides a preparation method of an antibacterial bone-promoting dual-function guiding bone regeneration film, which has strong bone growth-promoting and antibacterial effects, but the antibacterial film layer is covered outside the bone-growth promoting film layer, and the initial The effect of promoting bone growth film layer will be blocked, which will affect the effect of bone tissue repair and cannot realize dual functions at the same time

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