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Natural antioxidant nano composition containing total saponins of ginseng and preparation method of natural antioxidant nano composition

A technology of total ginseng saponins and nanocomposites can be applied to medical preparations containing active ingredients, cosmetic preparations, preparations for skin care, etc. Increases the effect of synergistic antioxidant action

Pending Publication Date: 2021-12-14
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Stabilizers in such nanosystems often play a purely stabilizing role, have no efficacy, and sometimes cause side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] 1.6 g of resveratrol was added into 80 ml of aqueous solution containing 0.4 g of total ginsenosides under stirring to form a coarse suspension. Transfer the coarse suspension to a pre-cooled high-pressure homogenizer at 0-5°C for homogenization, first cycle 5 times at 500 bar, and then cycle 15 times at 1300 bar to obtain the nanocomposite suspension, and measure the nanocomposite The average particle size of the suspension was 511 nm.

Embodiment 2

[0020] Add 1.6 g of quercetin to 80 ml of aqueous solution containing 0.4 g of total ginsenosides under stirring to form a coarse suspension. Transfer the coarse suspension to a pre-cooled high-pressure homogenizer at 0-5°C for homogenization, first cycle 5 times at 500 bar, and then cycle 15 times at 1300 bar to obtain the nanocomposite suspension, and measure the nanocomposite The average particle size of the suspension was 373 nm.

Embodiment 3

[0022] 1.6g curcumin was added under stirring in the 80ml aqueous solution containing 0.4g ginsenosides to form a coarse suspension. Transfer the coarse suspension to a pre-cooled high-pressure homogenizer at 0-5°C for homogenization, first cycle 5 times at 500 bar, and then cycle 15 times at 1300 bar to obtain the nanocomposite suspension, and measure the nanocomposite The average particle size of the suspension was 679 nm.

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Abstract

The invention relates to a natural antioxidant nano composition containing total saponins of ginseng and a preparation method of the natural antioxidant nano composition. The prescription of the invention comprises the following components in percentage by weight: 0.1-20% of antioxidant active matter, 0.1-20% of total ginsenoside as a stabilizer and the balance of water. According to the preparation method disclosed by the invention, the ginseng total saponins are adopted to replace the existing conventional chemical synthetic surfactants or high-molecular polymers to serve as the stabilizer, and a pure natural formula is adopted, so that the synergistic anti-oxidation effect is increased, and adverse effects such as side effects caused by other additives are reduced. The process is simple, the dosage is accurate, no organic reagent is adopted, and the method is suitable for large-scale production.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to a natural antioxidant nano composition containing total ginsenosides and a preparation method thereof. Background technique [0002] Naturally occurring antioxidant active substances such as resveratrol and quercetin have been proven to have better antioxidant effects than chemically synthesized benzohydroxamic acid and other whitening antioxidants with fewer skin side effects. However, most of these natural active substances have problems such as poor water solubility, which affects their actual effects. [0003] Nanosuspension or nanocrystals are composed of active ingredients, stabilizers (usually surfactants or polymers) and water. This technical system does not use any drug carrier, so it has the advantages of high drug loading, small side effects, and fast onset of action. It is an actual effect of enhancing insoluble ingredients by increasing saturation solubility and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/34A61K8/35A61K8/49A61K8/67A61Q19/08
CPCA61K8/9789A61K8/347A61K8/498A61K8/35A61K8/671A61K8/678A61K8/34A61Q19/08A61K2800/522A61K2800/413A61K2800/52
Inventor 刘涛
Owner QINGDAO UNIV OF SCI & TECH
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