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Polypeptide synthesis system

A technology of polypeptide synthesis and filtration system, applied in the field of polypeptide synthesis system, can solve the problems of blockage of through holes, lower solid-liquid separation efficiency and high viscosity, and achieve the effect of improving use efficiency and improving solid-liquid separation efficiency.

Pending Publication Date: 2021-12-17
邵杜娟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to make up for the deficiencies of the prior art and solve the problem of solid-liquid separation of the peptide synthesis raw materials in the prior art when the peptide synthesis raw materials are centrifuged, on the one hand, when the liquid raw materials are discharged, the liquid raw materials for polypeptide synthesis have higher viscosity, The liquid raw material is not easy to come out. On the other hand, when the raw material for polypeptide synthesis is centrifuged, the problem of clogging of the through hole in the centrifuge tank is likely to occur, thereby reducing the problem of solid-liquid separation efficiency; the present invention proposes a peptide synthesis system

Method used

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specific Embodiment approach

[0032] As a specific embodiment of the present invention, a group of No. 3 rods 16 is evenly fixed on the inner wall of the outer casing 1, and a No. 1 column 17 is fixedly connected to each No. 3 bar 16. 17 passes through the lower end of the inner housing 11 and is located inside the inner housing 11, the first number column 17 is rotatably connected to the lower end of the inner housing 11, and the outer ring of the first number column 17 is evenly fixed with a scraper 18;

[0033] During use, by fixing the No. 3 rod 16 on the inner wall of the outer shell 1, the No. 1 post 17 is fixed at the confluence of the No. 3 rods 16, so that the No. 1 post 17 passes through the bottom of the inner casing 11, and the No. 1 post 17 and the No. 1 post 17 are connected to each other. The lower end of the inner casing 11 is rotationally connected, and the outer ring of the first column 17 is uniformly fixed with a scraper 18, so that the scraper 18 is in contact with the inner wall of the...

Embodiment approach

[0036] As a specific embodiment of the present invention, one end of the No. 1 bump 14 close to the inner wall of the outer casing 1 is provided with a No. 1 groove 144, the side wall of the No. 1 groove 144 is the inner wall of the outer casing 1, and the No. 1 groove 144 runs through the upper and lower sides of the outer casing 1;

[0037] When in use, a No. 1 groove 144 is uniformly provided at the end of the No. 1 bump 14 close to the inner wall of the outer casing 1, so that the No. 1 groove 144 is close to the outer casing 1, so that the No. 1 groove 144 runs through the upper and lower ends of the outer casing 1. When the motor When 13 rotates, the motor 13 drives the inner casing 11 to rotate, and when the inner casing 11 rotates, the polypeptide synthesis raw material inside the inner casing 11 is impacted by the centrifugal force on the inner wall of the inner casing 11, so that the liquid raw material flows through the through hole 111, the liquid raw material impa...

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Abstract

The invention relates to the technical field of polypeptide synthesis, in particular to a polypeptide synthesis system. The system comprises a fermentation system, a filtering system and a drying system; the filtering system comprises a centrifugal filter, wherein the centrifugal filter comprises an outer shell, an inner shell, a shell cover and a motor; and when the motor rotates, the motor drives the inner shell to rotate, when the inner shell rotates, the polypeptide synthesis raw material inside the inner shell impacts the inner wall of the inner shell under the action of centrifugal force, so that the liquid raw material flows out of a through hole, impacts on a first convex block and is guided by the first convex block to flow downwards, when the liquid flows down from the upper part of the first convex block, the liquid raw material flows out of a first groove, so that the liquid raw material is prevented from being blocked by the first convex block, and the solid-liquid separation efficiency is improved.

Description

technical field [0001] The invention relates to the technical field of polypeptide synthesis, in particular to a polypeptide synthesis system. Background technique [0002] Peptide synthesis is a process of repeated addition of amino acids. The solid-phase synthesis sequence is generally synthesized from the C-terminus to the N-terminus; the past peptide synthesis was carried out in a solution called liquid-phase synthesis; since 1963, Merrifield successfully developed solid-phase peptides Since the synthesis method has been continuously improved and perfected, the solid-phase method has become a common technique in the synthesis of peptides and proteins today, showing the incomparable advantages of the classic liquid-phase synthesis method, thus greatly reducing the purification of each step of the product. Difficulty, and the process of peptide synthesis and purification needs to be fermented first, and then the fermented fermentation broth is subjected to centrifugal filt...

Claims

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Application Information

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IPC IPC(8): B04B1/06B04B7/08B04B7/12B04B7/16B04B7/02B04B9/04B04B11/08B04B15/06C07K1/34B01D36/00
CPCB04B1/06B04B7/08B04B7/12B04B7/16B04B7/02B04B9/04B04B11/08B04B15/06C07K1/34B01D36/00B04B2007/025
Inventor 邵杜娟张清
Owner 邵杜娟