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Preparation method of dendrobium alkaloid, medicine containing dendrobium alkaloid and application of dendrobium alkaloid in preparation of medicine for treating and inhibiting cholestasis

A dendrobium alkaloid and bile technology, which is applied in drug combinations, medical preparations containing active ingredients, and pharmaceutical formulas, can solve the problems of lack of therapeutic drugs and achieve the effect of improving bile acid efflux and efflux

Inactive Publication Date: 2021-12-21
安徽同济生生物科技有限公司
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Problems solved by technology

At present, there is a lack of clinically effective therapeutic drugs for most cholestasis diseases

Method used

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  • Preparation method of dendrobium alkaloid, medicine containing dendrobium alkaloid and application of dendrobium alkaloid in preparation of medicine for treating and inhibiting cholestasis
  • Preparation method of dendrobium alkaloid, medicine containing dendrobium alkaloid and application of dendrobium alkaloid in preparation of medicine for treating and inhibiting cholestasis
  • Preparation method of dendrobium alkaloid, medicine containing dendrobium alkaloid and application of dendrobium alkaloid in preparation of medicine for treating and inhibiting cholestasis

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preparation example Construction

[0029] The preparation method of dendrobase according to the third aspect of the invention, comprising the steps of:

[0030] S1, Huoshan Dendrobium 60 ° C drying to constant weight;

[0031] S2, the Dendrobium obtained by step S1 is pulverized, weighing 20 g, placed in a 500 ml round bottom flask, adding 50 ml of the buffer having the activated cellulase, stir well, and acquires mixed liquid A;

[0032] S3, the mixed liquid A obtained in step S2 is placed in an enzymatic solution in a 37 ° C environment, and then warmed to 90 ° C for 3 hours;

[0033] S4, 200 ml of anhydrous ethanol solution was added, and the water bath was cooled into a water bath, and the filtrate B was combined for 2 hours.

[0034] S5, the filtrate B obtained by step S4 is concentrated under reduced pressure to 100 mL, adding an equal volume chloroform to extract 3 times, and recovering chlorine to obtain a total dendrobium alkaloid.

[0035] According to the preparation method of dendrobase according to the...

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Abstract

The invention discloses a preparation method of dendrobium alkaloid, a medicine containing the dendrobium alkaloid and application of the dendrobium alkaloid in preparation of the medicine for treating and inhibiting cholestasis. The dendrobium alkaloid treatment has the obvious effect of protecting DDC from causing intrahepatic cholestasis liver injury, bile acid efflux can be improved by up-regulating Fxr expression, an upstream signal channel of a transcriptional regulation factor Nrf2 is enhanced to promote Nrf2 expression, and the expression quantity of a downstream target gene is further increased, so that the anti-oxidative stress effect of a body is enhanced.

Description

Technical field [0001] The present invention relates to the field of traditional Chinese medicine, and in particular, a method of preparing an alkaloid of dendrobases and a drug having it therefor and its application in the preparation of therapeutic inhibition of bile dredging drugs. Background technique [0002] Drug-induced bile gaseous liver injury is associated with liver lesions caused by bile formation and (or) excretion dysfunction, related to drug itself or its metabolites or allergic reactions. According to the difference in the cause of the disease, it can be divided into two types of intrahepatic and alpatic bile sludge. Currently, there is a lack of fruitful medical drugs for most bile sludge conditions. Therefore, it is especially important to find a drug that can alleviate bile sludge liver injury and is particularly important. Inventive content [0003] It is an object of the present invention to provide an application of Dendrobium alkaloids in the preparation o...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8984A61P1/16
CPCA61K36/8984A61P1/16A61K2236/19
Inventor 余茂耘韩际宏段亚君梁英权杨潇潇陈元利张丰陈贵兰葛玉
Owner 安徽同济生生物科技有限公司
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