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A kind of artificial amniotic bone synovium and preparation method thereof

A technology of amniotic membrane and synovium, applied in the field of biomedical materials, can solve the problems of easy calcification, insufficient mechanical strength, and body support of biological bone synovium, and achieve the effects of improving mechanical strength, blocking calcium salt deposition, and improving support

Active Publication Date: 2022-06-03
GUANGDONG PROPHET BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the biological bone synovium is easy to calcify, has poor durability, and has certain immunogenicity
At the same time, the current biological bone synovium is not strong enough to support the body

Method used

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  • A kind of artificial amniotic bone synovium and preparation method thereof
  • A kind of artificial amniotic bone synovium and preparation method thereof
  • A kind of artificial amniotic bone synovium and preparation method thereof

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Experimental program
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preparation example Construction

[0037] The mass concentration of the aqueous solution containing the amino group small molecular substance is 1-5%.

[0039] Specifically, the drug includes at least one of anti-infective drugs, anti-inflammatory drugs, and bacteriostatic drugs.

[0046] In some embodiments, the dehydrated amniotic membrane is treated with a decellularization reagent, wherein the decellularized

[0050] The mass concentration of the aqueous solution containing the amino group small molecular substance is 1-5%.

Embodiment 1

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Abstract

The invention provides an artificial amniotic bone synovium and a preparation method thereof. The artificial amniotic bone synovium comprises: an inner synovial layer and an outer synovial layer, the outer synovial layer is coated on the outer periphery of the inner synovial layer, the inner synovial layer Amniotic fluid is filled between the synovial layer and the outer synovial layer, the inner synovial layer is a polymer biomaterial loaded with slow-release drugs, and the outer synovial layer is the surface layer of amniotic basement membrane or liquefied and resolidified amniotic basement membrane fluid. In the artificial amniotic bone synovium of the present invention, the inner synovial layer is a macromolecule biomaterial loaded with slow-release drugs, and the outer synovial layer is the amniotic basement membrane or the amniotic basement membrane liquid surface layer that has been liquefied and resolidified; the loading of the inner synovial layer is slow Drug release acts precisely on the knee joint; the outer synovial layer can achieve rapid endothelialization and block calcium salt deposition, improve anti-calcification performance and retain its non-immunogenicity, prevent blood components and interstitial fluid components from infiltrating, calcium salt deposition and The formation of thrombus prolongs the use time.

Description

A kind of artificial amniotic bone synovium and preparation method thereof technical field The present invention relates to the technical field of biomedical materials, in particular to a kind of artificial amniotic bone synovium and preparation method thereof Law. Background technique [0002] The synovium is the inner layer of the joint capsule, light red, smooth and shiny, thin and soft, composed of loose connective tissue. joint cavity All structures within it, except the articular cartilage and the meniscus cartilage plate, are encased by the synovial membrane. The synovium secretes synovial fluid, which moves the joints play an important role in. The normal synovium is divided into two layers, a thin cellular layer (luminal layer) and a vascular layer (subintima), which are attached to non- The articular surface part covers the bony surface in the joint capsule. The knee joint acts as a place for balance, enabling a person to use both feet Bearing the weigh...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/36A61L27/20A61L27/22A61L27/24A61L27/54
CPCA61L27/3633A61L27/3604A61L27/24A61L27/225A61L27/222A61L27/20A61L27/3645A61L27/3687A61L27/54A61L2300/602A61L2400/18A61L2430/24
Inventor 周辉王月虹
Owner GUANGDONG PROPHET BIOTECHNOLOGY CO LTD
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