Preparation method of Xintong preparation

A preparation and volatile oil technology, applied in the field of traditional Chinese medicine, can solve the problems of reducing the antiasthmatic, antitussive, antispasmodic, sedative and antibacterial effects of the preparation, long extraction time, low extraction efficiency, etc., to improve product stability and clinical efficacy, extraction. The effect of short time and high extraction efficiency

Inactive Publication Date: 2022-01-04
SHANDONG NEWTIME PHARMA
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Problems solved by technology

[0007] In the above process, Pueraria lobata and Salvia miltiorrhiza are extracted by reflux of 70% ethanol, and the extraction temperature reaches 80°C, so that the heat-sensitive medicinal components in Pueraria lobata and Salvia miltiorrhiza are easily decomposed, the extraction time is long, the extraction ef

Method used

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  • Preparation method of Xintong preparation
  • Preparation method of Xintong preparation
  • Preparation method of Xintong preparation

Examples

Experimental program
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Effect test

Embodiment 1

[0049] The preparation of embodiment 1 Xintong oral liquid

[0050]

[0051] (1) Take Pueraria Radix and Salvia Miltiorrhiza raw medicinal material decoction pieces, add 8 times the amount of 70% ethanol solution and ultrasonically extract twice, each time for 1 hour, to obtain Pueraria Radix and Salvia Miltiorrhiza Ethanol Extract I and Medicinal Dregs I for future use;

[0052] (2) Take Angelica sinensis and Citrus aurantium raw medicinal material decoction pieces, add 6 times the amount of water respectively, extract the volatile oil by steam distillation, the extraction time is 4h, obtain 3.0mL of Angelica volatile oil I and Citrus aurantii volatile oil II 2.8mL, set aside;

[0053] (3) Take step (1) medicinal dregs Ⅰ, step (2) medicinal dregs Ⅱ, medicinal dregs Ⅲ and astragalus, Codonopsis Radix, Radix Polygoni Multiflori, Epimedium Folium, Saponaria thorn, seaweed, kelp, and oyster 9 raw materials Add water to decoct twice, first add 10 times the amount of water to de...

Embodiment 2

[0057] The preparation of embodiment 2 Xintong oral liquid

[0058]

[0059] (1) Take Pueraria Radix and Salvia Miltiorrhiza raw medicinal material decoction pieces, add 10 times the amount of 60% ethanol solution and ultrasonically extract for 3 times, each time for 0.5 h, to obtain Pueraria Radix and Salvia Miltiorrhiza Ethanol Extract I and Medicinal Dregs I for future use;

[0060] (2) Take angelica and citrus aurantium raw medicinal material decoction pieces, add 4 times the amount of water respectively, extract the volatile oil by steam distillation, and the extraction time is 6 hours, obtain 2.9 mL of volatile oil of angelica and 2.6 mL of volatile oil of citrus aurantium, and set aside;

[0061] (3) Take step (1) medicinal dregs Ⅰ, step (2) medicinal dregs Ⅱ, medicinal dregs Ⅲ and astragalus, Codonopsis Radix, Radix Polygoni Multiflori, Epimedium Folium, Saponaria thorn, seaweed, kelp, and oyster 9 raw materials Add water to decoct 2 times, first add 12 times the am...

Embodiment 3

[0065] The preparation of embodiment 3 Xintong oral liquid

[0066]

[0067] (1) Take Pueraria Radix and Salvia Miltiorrhiza raw medicinal material decoction pieces, add 6 times the amount of 80% ethanol solution and ultrasonically extract twice, each time for 2 hours, to obtain Pueraria Radix and Salvia Miltiorrhiza ethanol extract I and medicinal residue I, and set aside;

[0068] (2) Take angelica and citrus citrus raw medicinal material decoction pieces, add 8 times the amount of water respectively, and extract the volatile oil by steam distillation. The extraction time is 1h, and 2.5mL of volatile oil of angelica and 2.3mL of volatile oil of citrus citrus are obtained, and set aside;

[0069] (3) Take step (1) medicinal dregs Ⅰ, step (2) medicinal dregs Ⅱ, medicinal dregs Ⅲ and astragalus, Codonopsis Radix, Radix Polygoni Multiflori, Epimedium Folium, Saponaria thorn, seaweed, kelp, and oyster 9 raw materials Add water to decoct twice, first add 8 times the amount of w...

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Abstract

The invention belongs to the field of traditional Chinese medicine preparations, and particularly relates to a preparation method of a Xintong preparation. The Xintong preparation is prepared from the following 13 raw medicinal materials: astragalus membranaceus, codonopsis pilosula, radix ophiopogonis, polygonum multiflorum, longspur epimedium, radix puerariae, angelica sinensis, salvia miltiorrhiza, spina gleditsiae, seaweed, kelp, oyster and immature bitter orange. The preparation method comprises the following steps of: extracting the radix puerariae and the salvia miltiorrhiza by adopting an ultrasonic method, respectively extracting volatile oil of the angelica sinensis and the immature bitter orange, and performing cyclodextrin quantitative inclusion on the obtained volatile oil. The Xintong preparation prepared by the method is high in content of medicinal components and good in taste; the medication compliance of a patient is improved; and the stability and clinical curative effect of a Xintong preparation product are improved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and relates to a preparation method of a traditional Chinese medicine composition for treating coronary heart disease angina pectoris, in particular to a preparation method of Xintong preparation. Background technique [0002] Coronary heart disease and angina pectoris refer to angina pectoris caused by myocardial ischemia and hypoxia due to coronary artery sclerosis or spasm, accounting for about 90% of angina pectoris patients. The disease is a relatively common cardiovascular disease, and the middle-aged and elderly people have a high incidence. It is the most common cause of death in the population of developed countries in the world, and it is also the main cause of death in my country in the past two decades. It has become a major disease that threatens human health. one. Coronary heart disease and angina pectoris mostly occurred in middle-aged and elderly patients in ...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61K47/69A61P9/10A61K35/618
CPCA61K36/481A61K36/344A61K36/8968A61K36/704A61K36/296A61K36/488A61K36/232A61K36/537A61K36/483A61K36/02A61K36/03A61K35/618A61K36/752A61K47/6951A61P9/10A61K2236/333A61K2236/39A61K2236/331A61K2236/53A61K2300/00
Inventor 关永霞王立友张兰
Owner SHANDONG NEWTIME PHARMA
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