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Ophthalmic lubricating liquid composition and application thereof

A lubricating fluid composition, ophthalmic technology, applied in the directions of application, drug combination, chemicals for biological control, etc., can solve the problems of poor antimicrobial preservative effect, increased preservative addition, ocular surface toxicity, etc. Achieve the effect of improving wearing comfort, increasing viscosity and inhibiting dry eyes

Pending Publication Date: 2022-01-11
南京睿远医疗技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for solutions with high viscosity and water-soluble substances with high water content, the antimicrobial antiseptic effect is poor, and the conventional control measures are to increase the amount of preservatives in the solution or use special preservatives
A large number of studies have shown that ocular preparations with high preservative content are prone to ocular surface toxicity and / or irritation

Method used

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  • Ophthalmic lubricating liquid composition and application thereof
  • Ophthalmic lubricating liquid composition and application thereof
  • Ophthalmic lubricating liquid composition and application thereof

Examples

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Embodiment 1

[0046] The formula composition of embodiment 1 and comparative example 1-10 is as shown in table 1, table 2. The proportions of each component are percentages by mass.

[0047] The formula composition of table 1-embodiment 1 and comparative example 1-4

[0048]

[0049] Formulation composition of table 2-comparative examples 5-10

[0050]

[0051]

[0052] The lubricating liquid composition of the present invention is prepared by the following method:

[0053] (1) take each component respectively according to the formula quantity of table 1-2;

[0054] (2) Add part of purified water into the container, then add poloxamer 407 and polyethylene glycol respectively, then add purified water and stir for 30 minutes;

[0055] (3) Add polyvinylpyrrolidone, edetate disodium, tromethamine, sodium chloride and potassium chloride, add purified water and stir for 50 minutes;

[0056] (4) Add sodium hyaluronate, add purified water and stir for 90 minutes;

[0057] (5) Adjust the...

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Abstract

The invention relates to an ophthalmic lubricating liquid composition and application thereof. The ophthalmic lubricating liquid composition is compounded by selecting sodium hyaluronate with different molecular weights, polyvinylpyrrolidone and polyethylene glycol with a proper weight ratio are supplemented, under the synergistic effect of the components, the moisturizing and tackifying effects are achieved, the prepared lubricating liquid composition has excellent lubrication and moisture retention properties, dry eyes can be effectively inhibited, and the comfort level of wearing glasses is improved. According to the ophthalmic lubricating liquid composition, the biguanide preservative, tromethamine and edetate disodium are compounded to form a preservative system, and under the synergistic effect of the three, effective collision between the preservative and microorganisms is remarkably improved, so that the effect of effectively improving the corrosion resistance of the preservative and microorganisms can be achieved under the condition that the dosage of the biguanide preservative is not increased. Therefore, the lubricating liquid still has efficient corrosion resistance and biocompatibility.

Description

technical field [0001] The invention belongs to the technical field of contact lens lubricating fluid, and in particular relates to an ophthalmic lubricating fluid composition and an application thereof. Background technique [0002] Contact lenses are increasingly playing an important role in enhancing visual health due to their optical correction advantages, especially soft contact lenses are favored by more and more myopia patients due to their comfort and ease of use. Increase. [0003] When wearing contact lenses, two more contact surfaces are added to the eyes (from one corneal interface to three interfaces), resulting in accelerated tear evaporation and reduced tear wetting, and then the following symptoms will appear, such as: foreign body sensation and fatigue symptoms, irritation, itching, burning, increased blinking, conjunctival hyperemia, mucus discharge from the eyes, allergies to smoke, air conditioning and environmental factors, etc. According to reports, t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/79A61K31/728A61K31/77A61K47/18A61K9/00A61P27/02A61P27/04A61L12/14A01N37/44A01N33/04A01N47/44A01P3/00A01P1/00A61L101/50A61L101/48A61L101/46
CPCA61K31/79A61K31/728A61K31/77A61K47/183A61K47/18A61K9/0048A61P27/02A61P27/04A61L12/14A01N37/44A01N33/04A01N47/44A61L2101/50A61L2101/48A61L2101/46A61K2300/00
Inventor 郭亮亮
Owner 南京睿远医疗技术有限公司
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