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Application of golden larch bark acetic acid in preparation of medicine for treating pulmonary arterial hypertension

A technology of pulmonary arterial hypertension and vitex acetic acid, which is applied in the field of application of vitex acetic acid in the preparation of drugs for the treatment of pulmonary arterial hypertension, can solve the problems of unseen pulmonary hypertension and no obvious cytotoxicity of normal cells, and achieve high safety , the effect of broad application prospects

Active Publication Date: 2022-02-01
DALIAN MEDICAL UNIVERSITY
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  • Claims
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Problems solved by technology

In addition, it has been reported in the anti-tumor field that it has cytotoxic activity on tumor cells, but has no obvious cytotoxicity on normal cells.
However, there is no research report on its use in pulmonary arterial hypertension (Pulmonary Arterial Hypertension, PAH).

Method used

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  • Application of golden larch bark acetic acid in preparation of medicine for treating pulmonary arterial hypertension
  • Application of golden larch bark acetic acid in preparation of medicine for treating pulmonary arterial hypertension
  • Application of golden larch bark acetic acid in preparation of medicine for treating pulmonary arterial hypertension

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Embodiment 1

[0022] The application of embodiment 1 Vitex acetic acid in the treatment of pulmonary hypertension

[0023] 1. Animals and experimental reagents:

[0024] Mice (strain: Kunming mice, purchased from SPF Animal Experiment Center, Institute of Genome Engineering Model Animals for Major Diseases, Dalian Medical University),

[0025] 2. Establishment of hypoxia-induced pulmonary hypertension model:

[0026] Twenty-four healthy Kunming male mice (body weight 20-25 grams) were randomly divided into two groups according to the principle of body weight balance, namely the experimental group and the control group. The mice in the control group were reared in a standard aseptic feeding environment, and were randomly divided into two groups according to the principle of body weight balance, namely the normoxia+solvent group (solvent with the same volume as the turmeric acetic acid group, intraperitoneal injection method) and the normoxia+solvent group. Vitex acetic acid group (Vitex ac...

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Abstract

The invention discloses application of golden larch bark acetic acid in preparation of a medicine for treating pulmonary arterial hypertension. The invention belongs to the technical field of biological medicine. A pulmonary arterial hypertension disease mouse model is constructed through hypoxia (10%) induction. After the golden larch bark acetic acid is injected into the intraperitoneal cavity, the conditions of fur, diet, activity, death and the like of the pulmonary arterial hypertension mouse model are observed. Results show that the golden larch bark acetic acid (as shown in the formula I) has the effects of remarkably improving pulmonary vascular remodeling of animals with pulmonary hypertension, relieving right ventricular hypertrophy and right heart failure, improving the life quality of the animals with pulmonary hypertension (improving feeding and water inflow) and increasing the survival rate of the animals with pulmonary hypertension. Therefore, the golden larch bark acetic acid has a wide application prospect in the aspect of preventing and treating the pulmonary arterial hypertension disease.

Description

technical field [0001] The invention relates to pseudolaric acid B, (1R, 7S, 8R, 9R)-7-Acetoxy-9-((1E, 3E)-4-carboxy-penta-1,3-dienyl)-9- methyl-11-oxo-1(pseudolaric acid B, (1R, 7S, 8R, 9R)-7-acetoxy-9-((1E, 3E)-4-carboxy-penta-1,3-dienyl A new application of )-9-methyl-11-oxyl group-1), particularly relates to the application of fenugreek acetic acid in the preparation of medicines for treating pulmonary hypertension. The invention belongs to the technical field of biomedicine. Background technique [0002] Pulmonary Arterial Hypertension (PAH) is a progressive malignant cardiovascular disease caused by many reasons. The etiology is complex, but it has similar pathophysiological changes. Hypertrophy, muscularization of pulmonary arterioles, fibrous hyperplasia of vascular intima, stenosis and occlusion of the lumen accompanied by in situ thrombus formation. The main symptoms are dyspnea, decreased exercise capacity and progressive right heart failure leading to death. C...

Claims

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Application Information

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IPC IPC(8): A61K31/366A61K36/15A61P11/00A61P9/12A61P9/04A61P9/00A61K125/00
CPCA61K31/366A61K36/15A61P11/00A61P9/12A61P9/04A61P9/00
Inventor 沈婷婷刘丕旭牛文慧黄丹
Owner DALIAN MEDICAL UNIVERSITY
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