Preparation and application method of macrolide antibiotic molecularly imprinted magnetic metal organic framework composite material

A technology of metal-organic frameworks and macrolides, applied in the fields of alkali metal compounds, chemical instruments and methods, alkali metal oxides/hydroxides, etc., to achieve good adsorption selectivity, rapid solid-liquid separation, and large adsorption capacity Effect

Pending Publication Date: 2022-02-08
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The invention provides a preparation and application method of a molecularly imprinted magnetic metal-organic framework composite material of macrolide antibiotics, which solves the problem that it is difficult for traditional molecularly imprinted polymers to achieve efficient adsorption and separation of multiple macrolide antibiotics at the same time question

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] (1) Weigh 0.65g of anhydrous ferric trichloride and 0.3g of sodium citrate in 20mL of ethylene glycol, stir under ultrasonic conditions to make them completely dissolve; then add 1.2g of sodium acetate, and quickly After stirring for 1 h, a brown-yellow homogeneous solution was formed. The mixed homogeneous solution was transferred to a 50mL polytetrafluoroethylene liner, packaged into a stainless steel reactor, and reacted at 200°C for 12h. After the reaction was finished and cooled, the material was washed sequentially with ethanol and ultrapure water, and a rapid solid-liquid separation was achieved with a magnet until the washing liquid was completely clarified, and finally the product ferroferric oxide was stored in 30 mL of ethanol solution.

[0055] Add 8mL of water to the above iron ferric oxide storage solution, ultrasonically disperse for 30min, add 0.6mL of ammonia water, add 0.6mL of tetraethyl orthosilicate dropwise in the mixed solution of 4mL of ethanol u...

Embodiment 2

[0062] Performance tests were performed on the macrolide antibiotic molecularly imprinted magnetic metal-organic framework composites and non-imprinted composites prepared in Example 1.

[0063] (1) Get 10 mg of imprinted composite material and non-imprinted composite material prepared in Example 1, add to 50mL, 20mg / L macrolide antibiotics mix (comprising erythromycin, clarithromycin, roxithromycin , acetylspiramycin, beilimycin and tylosin, the molar ratio of which is 1:1:1:1:1:1) in an aqueous solution, at 25°C, 150rpm, whirling adsorption for 2h, using high performance liquid chromatography The concentration of each target substance in the solution before and after adsorption was detected respectively, and the adsorption amount of macrolide antibiotics by imprinted composite material and non-imprinted composite material was obtained, and the imprinting factor was obtained by the ratio analysis of the adsorption amount of the two.

[0064] The results showed that under the ...

Embodiment 3

[0079] The macrolide antibiotic molecularly imprinted magnetic metal-organic framework composite material prepared in Example 1 was tested for removal of macrolide antibiotics in simulated environmental water samples.

[0080] Collect certain river water sample, be configured as the macrolide antibiotic (comprising clarithromycin, roxithromycin, acetylspiramycin, beilimycin and tylosin with the concentration of 0.1mg / L, its molar ratio is 1:1:1:1:1) of the spiked water sample, take 20 mg of the imprinted composite material prepared in Example 1, at room temperature, 150rpm whirling adsorption for 2h, magnetically separate the imprinted composite material after adsorption, and use a small amount of ultrapure water After washing the material, add 2 mL of a mixed solution of acetic acid / methanol (volume ratio 2:8), elute for 1 h at 180 rpm, measure the concentration of the target substance in the eluent, and calculate the effect of the material on the macrolides in the water sampl...

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Abstract

The invention belongs to the technical field of adsorption materials, and relates to a preparation and application method of a macrolide antibiotic molecularly imprinted magnetic metal organic framework composite material. The material combines the excellent pore characteristics of a metal organic framework and the high selectivity of a molecularly imprinted polymer, can specifically adsorb erythromycin, clarithromycin, roxithromycin, acetylspiramycin, korubicin and tylosin in an aqueous solution, and is relatively large in adsorption capacity and relatively short in equilibrium time, and the material has relatively high removal efficiency on low-concentration macrolide antibiotics. The material has superparamagnetism, can quickly realize solid-liquid separation, and can be repeatedly used for multiple times. The material is used as a solid-phase extraction adsorbent and is combined with high performance liquid chromatography, so that trace macrolide antibiotics in a complex environmental water sample can be analyzed and detected.

Description

technical field [0001] The invention belongs to the field of adsorption materials, and relates to a method for preparing and applying a macrolide antibiotic molecularly imprinted magnetic metal-organic framework composite material. [0002] technical background [0003] As the earliest class of ribosome-targeting antibiotics, macrolide antibiotics have the characteristics of low toxicity and wide pharmacological effects. widely used. Today's most typical macrolide antibiotics contain a 14-16-membered lactone ring, such as erythromycin, clarithromycin, roxithromycin, acetylspiramycin, beilimycin, tylosin, etc. Macrolide antibiotics are the most widely used type of antibiotics in China, especially in the aquaculture and animal husbandry industries where they are abused and discharged indiscriminately, causing water environment pollution. Compared with typical water environment pollution indicators, the proportion of antibiotic pollution indicators is not high, but the long-te...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/28B01J20/22B01J20/30C02F1/28C02F101/34C02F101/38
CPCB01J20/28009B01J20/226C02F1/285C02F2101/34C02F2209/02C02F2101/38
Inventor 马晓国刘怡扬张恒源
Owner GUANGDONG UNIV OF TECH
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