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Novel application of STM2457

A technology of 1. STM2457 and derivatives, applied in the field of STM2457 research

Active Publication Date: 2022-02-15
XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The application of STM2457 in NSCLC has not been reported yet, whether it can be used as a new NSCLC treatment strategy needs further study

Method used

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  • Novel application of STM2457
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  • Novel application of STM2457

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Embodiment Construction

[0055] The present invention is described further below:

[0056] The first aspect of this part introduces the use of STM2457 in the treatment of some diseases:

[0057] Application of STM2457 in the preparation of drugs for preventing and treating tumor diseases.

[0058] In some embodiments, the neoplastic disease is lung cancer.

[0059] In some embodiments, the lung cancer is non-small cell lung cancer; the concentration of STM2457 is 5 μM.

[0060] STM2457 can overcome tumor heterogeneity while effectively inhibiting the metastasis of tumor cells. And then provide new treatment ideas and products for the treatment of related tumors.

[0061] The second aspect of this part introduces the use of STM2457 in some mechanism adjustments:

[0062] The application of STM2457 in the preparation of at least one of preparations for inhibiting proliferation of NSCLC cells, preparations for inhibiting metastasis of NSCLC cells, and preparations for promoting apoptosis of NSCLC...

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Abstract

The invention belongs to the technical field of STM2457 research, and particularly relates to novel application of STM2457. The invention relates to application of STM2457 in preparation of medicines for preventing and treating tumor diseases. In some embodiments, lung cancer is non-small cell lung cancer; and the action concentration of the STM2457 is 5 [mu]M. The invention also discloses application of the STM2457 in preparation of at least one selected from the group consisting of an NSCLC cell retardation proliferation preparation, an NSCLC cell transfer inhibitor and an NSCLC cell apoptosis promoting preparation. The invention also relates to application of the STM2457 in preparation of a CYP19A1 expression inhibitor. The expression of the CYP19A1 is a CYP19A1 protein; and the action concentration of the STM2457 is 5 [mu]M. The invention further relates to application of the STM2457 in preparation of an estrogen signal channel inhibitor. The estrogen signal channel is an NSCLC associated estrogen signal channel. The invention also relates to application of the STM2457 in preparation of an METTL3 activity inhibitor. The invention develops a novel therapeutic drug for NSCLC, provides a novel therapeutic scheme, and is expected to inhibit the progress of NSCLC on the basis of overcoming tumor heterogeneity; and an effective activity inhibitor is provided for METTL3, and the change rule of molecular targets and the potential mechanism of tumor inhibition are clarified. Meanwhile, other novel application of the STM2457 is researched.

Description

technical field [0001] The invention belongs to the technical field of STM2457 research, and in particular relates to a new application of the STM2457. Background technique [0002] In China and even in the world, the mortality rate of lung cancer, especially non-small cell lung cancer (NSCLC), ranks first among all tumors, and tumor metastasis significantly reduces the survival rate of NSCLC patients. Due to the high burden of NSCLC and the high proportion of advanced NSCLC metastasis in my country, it is urgent to discover new targets to inhibit NSCLC metastasis and develop new strategies for the treatment of advanced NSCLC. [0003] In recent decades, NSCLC has been further defined as a unique group of diseases with genetic and cellular heterogeneity, which is characterized by a variety of cell collections in the tumor focus, and these cells have different genetic and molecular characteristics. Different sensitivities provide fertile ground for drug tolerance and serious...

Claims

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Application Information

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IPC IPC(8): A61K31/519A61P35/00A61P35/04
CPCA61K31/519A61P35/00A61P35/04
Inventor 肖晗廖永德
Owner XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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