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Mechanical bionic absorption filler and manufacturing method

A filler and mechanics technology, applied in the field of mechanical bionic absorption filler and production, can solve the problems of easy formation of agglomerates, nodules, mechanical incompatibility, and failure to achieve expected effects, and achieve the effect of easy injection

Pending Publication Date: 2022-02-18
GUANGZHOU YICHENG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Products currently on the market for facial fillers have the following disadvantages: (1) mechanical incompatibility due to material or formula problems, too soft will easily deform after implantation, and the expected effect will not be achieved, and too hard will easily form agglomerates and lumps (2) The volume or physical properties of the absorbable material will change with the degradation, resulting in the deformation or displacement of the implanted material during the degradation process; (3) The most commonly used filling material is through the cross-linking of sodium hyaluronate In order to improve the mechanical properties of the material, this method has certain beneficial effects, but the cross-linking process increases the safety risk, and cannot avoid the above shortcomings

Method used

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  • Mechanical bionic absorption filler and manufacturing method
  • Mechanical bionic absorption filler and manufacturing method
  • Mechanical bionic absorption filler and manufacturing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] S1. Add sodium hyaluronate powder with a molecular weight of 1.58 million and 2.2 parts by weight into PBS buffer solution with a mass part of 62.8, and stir for 2 hours at a stirring speed of 150 rpm to completely dissolve sodium hyaluronate in PBS buffer solution middle;

[0042] S2. Pour the dissolved solution into a mixing instrument, add 35 parts by mass of PCL microspheres with a particle size range of 40 to 50 microns, and stir while homogeneously shearing for 30 minutes at a stirring speed of 100 rpm. Speed ​​10000rpm;

[0043] Turn off the homogeneous shear, turn on the vacuum pump, and evacuate the vacuum in the container to below -0.08MPa, keep it for 2 hours, eliminate air bubbles and mix evenly;

Embodiment 2

[0045] S1. Add sodium hyaluronate powder with a molecular weight of 2 million and 2 parts by weight to normal saline with a mass part of 88, and stir for 2 hours at a stirring speed of 150 rpm, so that the sodium hyaluronate is completely dissolved in the normal saline;

[0046] S2. Pour the dissolved solution into a mixing instrument, add 10 parts by mass of PLGA microspheres with a particle size range of 10 to 45 microns, and stir while homogeneously shearing for 30 minutes at a stirring speed of 100 rpm. Speed ​​10000rpm;

[0047] Turn off the homogeneous shear, turn on the vacuum pump, and evacuate the vacuum in the container to below -0.08MPa, keep it for 2 hours, eliminate air bubbles and mix evenly;

Embodiment 3

[0049] S1. Add sodium hyaluronate powder with a molecular weight of 3 million and a weight part of 1.2 to a PBS buffer solution with a mass part of 73.8, and stir for 2 hours at a stirring speed of 150 rpm to completely dissolve the sodium hyaluronate in the PBS buffer solution middle;

[0050] S2. Pour the dissolved solution into a mixing instrument, add 25 parts by mass of PGCL microspheres with a particle size range of 20 to 75 microns, and stir while homogeneously shearing for 30 minutes at a stirring speed of 100 rpm. Speed ​​10000rpm;

[0051] Turn off the homogeneous shear, turn on the vacuum pump, and evacuate the vacuum in the container to below -0.08MPa, keep it for 2 hours, eliminate air bubbles and mix evenly;

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Abstract

The invention discloses a mechanical bionic absorption filler manufacturing method, which comprises: absorbable polyester microspheres, sodium hyaluronate and dispersion liquid, the absorbable polyester microspheres are homopolymers and / or copolymers of PLA, and / or PCL, and / or PGA and PDO capable of absorbing synthetic polyester materials, the sodium hyaluronate is non-crosslinked high-molecular-weight sodium hyaluronate, the dispersion liquid is a buffer solution, and / or normal saline, and / or water for injection, and provides osmotic pressure similar to that of cell sap and pH similar to that of tissue sap for the product, the preparation method is simple, safe and reliable, and the product has the performance of being easy to inject, degradable and free of obvious change in viscoelasticity in the degradation process; the filling material can improve the similar viscoelasticity of facial tissues, the viscoelasticity of the filling material does not change obviously within a certain degradation period, and the material does not cause new potential safety risks.

Description

technical field [0001] The invention relates to the technical field of bionic absorption filling, in particular to a mechanical bionic absorption filling and a manufacturing method. Background technique [0002] Products currently on the market for facial fillers have the following disadvantages: (1) mechanical incompatibility due to material or formula problems, too soft will easily deform after implantation, and the expected effect will not be achieved, and too hard will easily form agglomerates and lumps (2) The volume or physical properties of the absorbable material will change with the degradation, resulting in the deformation or displacement of the implanted material during the degradation process; (3) The most commonly used filling material is through the cross-linking of sodium hyaluronate To improve the mechanical properties of materials, this method has certain beneficial effects, but the cross-linking process increases the safety risk, and cannot avoid the above-...

Claims

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Application Information

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IPC IPC(8): A61L27/58A61L27/50A61L27/26
CPCA61L27/58A61L27/50A61L27/26A61L2400/06A61L2430/34C08L5/08C08L67/04
Inventor 金振华区京华王立杰
Owner GUANGZHOU YICHENG BIOTECH CO LTD
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