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ZnO@Fe3O4 nano-liposome and preparation method thereof and application thereof in removal of drug-resistant bacteria

A nano-liposome, liposome technology, applied in chemical instruments and methods, water/sludge/sewage treatment, metal/metal oxide/metal hydroxide catalyst, etc., can solve the problems of low sterilization efficiency, etc. Achieve the effect of improving sterilization efficiency, reducing the risk of drug resistance, and improving utilization

Pending Publication Date: 2022-02-18
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, constructing a magnetic nanoliposome that has a photocatalytic effect, can act in cells, and can be recycled repeatedly is an important direction to solve the problem of ion dissolution and low sterilization efficiency.

Method used

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  • ZnO@Fe3O4 nano-liposome and preparation method thereof and application thereof in removal of drug-resistant bacteria
  • ZnO@Fe3O4 nano-liposome and preparation method thereof and application thereof in removal of drug-resistant bacteria
  • ZnO@Fe3O4 nano-liposome and preparation method thereof and application thereof in removal of drug-resistant bacteria

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] According to one aspect of the present invention, this embodiment provides a kind of preparation method of the magnetic nanoliposome with bactericidal property, comprises the following steps:

[0030] (1) Preparation of magnetic OA-ZnO@Fe 3 o 4Nanoparticles: Disperse 0.25g of magnetic ferric ferric oxide and 1.0g of zinc acetate dihydrate in 100mL of methanol, put them in an ultrasonic instrument for 4min, and slowly add 0.03M sodium hydroxide dropwise to the above suspension under nitrogen protection Add 20mL of methanol solution dropwise within 30min, then continue to heat and stir, use an external magnetic field to remove excess supernatant, wash the precipitate with deionized water, and transfer it to a vacuum drying oven for overnight drying. Take the above nanoparticles and dissolve them in 30mL Slowly drop 1.0 g of oleic acid in absolute ethanol, stir continuously at a temperature of 60°C, recover through a magnetic field, and freeze-dry;

[0031] (2), ZnO@Fe ...

Embodiment 2

[0033] According to one aspect of the present invention, this embodiment provides a kind of preparation method of the magnetic nanoliposome with bactericidal property, comprises the following steps:

[0034] (1) Preparation of magnetic OA-ZnO@Fe 3 o 4 Nanoparticles: Disperse 0.30g of magnetic ferric iron tetroxide and 0.75g of zinc acetate dihydrate in 100mL of methanol, put them in an ultrasonic instrument for 5min, and slowly add 0.03M sodium hydroxide dropwise to the above suspension under nitrogen protection Add 20 mL of methanol solution dropwise within 30 minutes, then continue to heat and stir, use an external magnetic field to remove excess supernatant, wash the precipitate with deionized water, and transfer it to a vacuum drying oven for overnight drying. Take the above nanoparticles and dissolve them in 50 mL Slowly drop 1.2 g of oleic acid in absolute ethanol, stir continuously at a temperature of 60°C, recover through a magnetic field, and freeze-dry;

[0035] (2...

Embodiment 3

[0037] According to one aspect of the present invention, this embodiment provides a kind of preparation method of the magnetic nanoliposome with bactericidal property, comprises the following steps:

[0038] (1) Preparation of magnetic OA-ZnO@Fe 3 o 4 Nanoparticles: Disperse 0.35g of magnetic ferric iron tetroxide and 0.60g of zinc acetate dihydrate in 100mL of methanol, put them in an ultrasonic instrument for 3min, and slowly add 0.03M sodium hydroxide dropwise to the above suspension under nitrogen protection Add 30 mL of methanol solution dropwise within 30 minutes, then continue to heat and stir, use an external magnetic field to remove excess supernatant, wash the precipitate with deionized water, and transfer it to a vacuum drying oven for overnight drying. Take the above nanoparticles and dissolve them in 40 mL Slowly drop 0.5 g of oleic acid in absolute ethanol, stir continuously at a temperature of 60°C, recover through a magnetic field, and freeze-dry;

[0039] (2...

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Abstract

The invention belongs to the field of environmental functions and biological materials, and particularly relates to a novel magnetic nano-liposome composition ZnO@Fe3O4 nano-liposome which has photocatalytic performance and uses photothermal therapy for removing antibiotic drug-resistant bacteria and drug-resistant genes in water as well as a preparation method and application thereof, namely, a ZnO@Fe3O4 nano-liposome and a preparation method and application thereof in removal of drug-resistant bacteria. The ZnO@Fe3O4 nano-liposome is composed of a bactericidal material which takes soybean phosphatidylcholine and cholesterol as membrane materials and wraps oleic acid modified ZnO and magnetic Fe3O4 nano-particles. The magnetic liposome provided by the invention has a remarkable reduction effect on drug-resistant bacteria in a water environment.

Description

technical field [0001] The invention belongs to the field of environmental functions and biological materials, and specifically relates to a new magnetic nanoliposome composition-ZnO@Fe with photocatalytic properties and photothermal therapy used to remove antibiotic-resistant bacteria and drug-resistant genes in water 3 o 4 Nanoliposome and its preparation method and application. Background technique [0002] In recent years, the abuse of antibiotics has led to the widespread existence of drug-resistant bacteria in various water bodies. The continuous spread of resistance genes in the environment has made the problem of microbial resistance increasingly serious. As a hot spot for the spread of drug resistance, water treatment systems are closely related to human health. It is closely related to safety, so it is necessary to study new bactericidal technologies for water disinfection. Nanotechnology is a technology for studying materials and applications with a size in the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J31/02B01J23/80B01J35/02C02F1/30B01J35/00
CPCB01J31/0268B01J31/0271B01J23/80C02F1/30C02F2305/10C02F2305/08C02F2303/04B01J35/398B01J35/39B01J35/23B01J35/33B01J35/40
Inventor 陈红刘喆林泽俊帅馨怡
Owner ZHEJIANG UNIV
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