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Isoaspartic acid analysis method and mass spectrometry device

A technology of isoaspartic acid and analysis method, applied in mass spectrometers, analytical materials, measuring devices, etc., can solve the problems of unclear definitions of c ions and z ions, etc.

Pending Publication Date: 2022-03-04
SHIMADZU SEISAKUSHO CO LTD +1
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  • Abstract
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Problems solved by technology

It should be noted that the product ion generated from a precursor ion derived from a peptide containing an isoaspartic acid residue is expressed based on the c ion and z ion of a peptide containing an aspartic acid residue because: Aspartic acid residues have different bonds from the peptide backbone of aspartic acid residues, c-ions, z-ions are not well defined

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  • Isoaspartic acid analysis method and mass spectrometry device
  • Isoaspartic acid analysis method and mass spectrometry device
  • Isoaspartic acid analysis method and mass spectrometry device

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Embodiment Construction

[0038] An embodiment of the mass spectrometry device according to the present invention will be described below with reference to the accompanying drawings. The mass spectrometer in this embodiment is an ion trap-time-of-flight (IT-TOF) mass spectrometer.

[0039] figure 1A schematic configuration of an ion trap-time-of-flight mass spectrometer (hereinafter also simply referred to as "mass spectrometer") of this embodiment is shown in . The mass spectrometry apparatus of this embodiment is equipped with inside a vacuum chamber which maintains a vacuum atmosphere and is not shown in the figure: an ion source 1 for ionizing components in a sample; an ion trap 2 for ionizing The function is to capture the ions generated by the ion source 1; the time-of-flight mass separation part 3 is used to separate the ions ejected from the ion trap 2 according to the mass-to-charge ratio; and the ion detector 4 is used to separate the separated ions. detection. The ion trap mass spectrome...

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Abstract

A method for analyzing isoaspartic acid by dissociating precursor ions derived from a sample component to generate product ions and analyzing the product ions, the method comprising a step for irradiating the precursor ions with hydrogen radicals or radicals having oxidizing ability to dissociate the precursor ions to generate product ions, and a step for analyzing isoaspartic acid by irradiating the product ions with hydrogen radicals or radicals having oxidizing ability. The product ions are separated and detected in accordance with the mass-to-charge ratio, and product ions derived from isoaspartic acid are identified on the basis of the mass-to-charge ratio of the product ions.

Description

technical field [0001] The present invention relates to an analysis method of isoaspartic acid and a mass spectrometry device for implementing the analysis method. Background technique [0002] It has been reported that aspartic acid, one of the amino acids constituting proteins, isomerizes over time to isoaspartic acid, which is a major cause of cataracts (for example, Non-Patent Document 1). Therefore, analyzing the isoaspartic acid contained in the peptide contained in the metabolites of the living body, and inferring the degree of isoaspartic acid accumulated in the body based on the result is important for grasping the risk of cataract or studying for Potentially effective in cataract prevention strategies. [0003] In order to identify high-molecular compounds such as proteins, mass spectrometry is widely used in which ions (precursor ions) derived from high-molecular compounds are dissociated once or more to generate product ions (also called fragment ions), and the ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/62
CPCG01N27/62G01N33/6848G01N33/6812G01N2800/166H01J49/0045G01N27/64H01J49/0031H01J49/14H01J49/40
Inventor 高桥秀典浅川大树
Owner SHIMADZU SEISAKUSHO CO LTD
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