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Application of 18 beta-glycyrrhetinic acid in preparation of depression-related neuronal protection medicine

A technology of neuron protection and glycyrrhetinic acid, which is applied in the field of biomedicine, can solve the problems of lack of development of neuron protection drugs related to depression, and achieve the effect of reducing neuron cell apoptosis, good effect, and no side effects

Pending Publication Date: 2022-03-11
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of this application is to provide an application of 18β-glycyrrhetinic acid in the preparation of neuroprotective drugs related to depression, aiming to solve the problem of lack of corresponding drug development of neuroprotective drugs related to depression in the prior art

Method used

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  • Application of 18 beta-glycyrrhetinic acid in preparation of depression-related neuronal protection medicine
  • Application of 18 beta-glycyrrhetinic acid in preparation of depression-related neuronal protection medicine
  • Application of 18 beta-glycyrrhetinic acid in preparation of depression-related neuronal protection medicine

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] A pharmaceutical composition for treating depression-related neuron protection

[0047] The pharmaceutical composition includes 18β-glycyrrhetinic acid and pharmaceutically acceptable auxiliary agents, wherein the effective concentration of 18β-glycyrrhetinic acid is 10.0 mg / kg.

[0048] Moreover, the dosage form of the pharmaceutical composition is one of tablets, pills, capsules, granules, powders, liquids, emulsions, suspensions, ointments, injections, and skin patches. One or more of agents, binders, emulsifiers, lubricants, glidants, and colorants.

Embodiment 2

[0050] A pharmaceutical composition for treating depression-related neuron protection

[0051] The pharmaceutical composition includes 18β-glycyrrhetinic acid and pharmaceutically acceptable auxiliary agents, wherein the effective concentration of 18β-glycyrrhetinic acid is 20 mg / kg.

[0052] Moreover, the dosage form of the pharmaceutical composition is one of tablets, pills, capsules, granules, powders, liquids, emulsions, suspensions, ointments, injections, and skin patches. One or more of agents, binders, emulsifiers, lubricants, glidants, and colorants.

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Abstract

The invention belongs to the technical field of biological medicines, and particularly relates to application of 18 beta-glycyrrhetinic acid in preparation of a depression-related neuronal protection medicine. The application specifically comprises the following steps: 18 beta-glycyrrhetinic acid can play a role in protecting neurons by inhibiting depression-related microglial cell activation-mediated neuronal apoptosis; meanwhile, the 18beta-glycyrrhetinic acid can activate a nuclear transcription factor Nrf-2 related to depression to start transcription and translation of a brain-derived nerve growth factor so as to play a role in protecting neuronal cells, and the 18beta-glycyrrhetinic acid is obvious in drug effect and free of obvious side effects.

Description

technical field [0001] The application belongs to the technical field of biomedicine, and in particular relates to the application of 18β-glycyrrhetinic acid in the preparation of neuron protection drugs related to depression treatment. Background technique [0002] Depression is a chronic comprehensive disease with persistent low mood, loss of interest, and decreased will as the core symptoms. It is a common mental disease and has the characteristics of high recurrence rate, high disability rate, and high suicide rate. According to the report of the World Health Organization in 2017, there are 322 million people with depression in the world, the incidence rate is about 4.4%, and there is a problem of recurrent depression and chronicity; depression is also the biggest cause of disability (global depression more than 50 million people are disabled) and are the leading cause of suicide. In my country, there are more than 54 million patients with depression, and the lifetime p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61P25/24A61P25/00
CPCA61K31/56A61P25/24A61P25/00
Inventor 陈家旭何亮亮邓丽娟姚伟甘华莫晓玮唐凯锐杨可枫姚志红
Owner JINAN UNIVERSITY
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