Application of AIE photosensitizer as photodynamic method tooth bleaching agent and photodynamic method tooth bleaching agent

A photodynamic and bleaching agent technology, which is applied in the direction of medical preparations containing active ingredients, dental preparations, and cosmetic preparations, etc., to achieve the effect of simple operation

Pending Publication Date: 2022-03-15
天津市口腔医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no experimental research on the application of AIE photosensitizers in the field of tooth bleaching at home and abroad.

Method used

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  • Application of AIE photosensitizer as photodynamic method tooth bleaching agent and photodynamic method tooth bleaching agent
  • Application of AIE photosensitizer as photodynamic method tooth bleaching agent and photodynamic method tooth bleaching agent
  • Application of AIE photosensitizer as photodynamic method tooth bleaching agent and photodynamic method tooth bleaching agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] AIE TPA-Ph-Py powder was dissolved in dimethyl sulfoxide (DMSO) to obtain an AIE photosensitizer solution with a concentration of 1 mg / mL. Add hyaluronic acid with a molecular weight of 200,000 as a thickener to the solution at a mixing ratio of 1:50 to make it into a gel. The product is a photodynamic tooth bleaching agent. The role of the thickener is to ensure that it will not fall off when applied on the surface of the teeth, and the safety is guaranteed.

[0041] AIE TPA-Ph-Py synthesis route and NMR spectrum are attached Figure 5-6 .

[0042] AIE TPA-Ph-Py NMR data are as follows:

[0043] 1H NMR (400MHz, DMSO) δ9.47(s, 1H), 9.06–8.83(m, 2H), 8.20(t, J=7.0Hz, 1H), 7.94(d, J=8.0Hz, 2H), 7.82 (d,J=7.9Hz,2H),7.56(d,J=8.2Hz,2H),7.47–7.28(m,5H),7.22(d,J=16.4Hz,1H),7.08(dd,J= 17.8,7.6Hz,6H),6.97(d,J=8.1Hz,2H),4.45(s,4H).

Embodiment 2-6

[0045]The preparation methods of Examples 2-6 are similar to those of Example 1, the only difference being the selection of specific parameters (see Table 1 for details).

[0046] Table 1 embodiment parameter summary table

[0047]

[0048] AIE TPA-Py synthesis path and NMR spectrum are attached Figure 7-8 .

[0049] AIE TPA-Py NMR data are as follows:

[0050] 1H NMR (400MHz, DMSO) δ9.05 (d, J = 6.2Hz, 2H), 8.59 (d, J = 6.2Hz, 2H), 8.36–8.21 (m, 4H), 8.07 (dd, J = 20.9, 8.3Hz, 4H), 7.88(d, J=8.3Hz, 2H), 7.73(d, J=8.5Hz, 2H), 7.36(t, J=7.7Hz, 4H), 7.17–6.90(m, 8H) ,4.35(s,3H).

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Abstract

The invention belongs to the field of AIE tooth bleaching application, and particularly relates to application of an AIE photosensitizer as a photodynamic method tooth bleaching agent and the photodynamic method tooth bleaching agent. The method has the beneficial effects that adverse effects caused by high-concentration hydrogen peroxide, such as enamel surface microstructure changes (including enamel surface roughness and calcium and phosphorus content changes), are reduced; the bleaching effect is obvious, and the instant bleaching effect is equivalent to or slightly superior to the effect of high-concentration hydrogen peroxide; the bleaching effect is rapid, the obvious effect can be obtained in a single treatment course, and the action time is about 20 minutes; the operation is simple.

Description

technical field [0001] The invention belongs to the application field of AIE tooth bleaching, and relates to the application of an AIE photosensitizer as a photodynamic tooth bleaching agent and the photodynamic tooth bleaching agent. Background technique [0002] Clinically, tooth whitening can be achieved through full crown restoration and veneer restoration, but these techniques must grind and cut the enamel, which will cause irreversible damage to the tooth. In contrast, tooth bleaching involves chemical bleaching, which is quick, effective, non-destructive to the tooth structure and minimally invasive. At present, hydrogen peroxide is the most commonly used tooth bleaching agent. If you want to achieve the ideal bleaching effect, you usually need high concentration hydrogen peroxide (35%-40%) or long-term exposure (usually more than several hours) . Tooth bleaching involves changing the colored substances in the tooth structure, that is, through the redox reaction of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/49A61K8/46A61K8/73A61Q11/00
CPCA61K8/735A61K8/46A61K8/4913A61Q11/00A61K2800/81
Inventor 申静王俊华高静张茜玉丁丹
Owner 天津市口腔医院
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