Application of hyperoside in preparation of medicine for preventing and treating retina degenerative diseases

A technology of retinal degeneration and hyperin, applied in the field of medicine, can solve problems such as unreported hyperin activity, and achieve the effect of treating and improving retinal degeneration and significant retinal degeneration

Pending Publication Date: 2022-03-15
YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Existing literature has not yet reported that hyperoside is effective in the treatment of retinal degenerative diseases such as age-related macular degeneration, retinitis pigmentosa, Stargardt disease, cone-rod dystrophy, etc. Aspects of activity

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of hyperoside in preparation of medicine for preventing and treating retina degenerative diseases
  • Application of hyperoside in preparation of medicine for preventing and treating retina degenerative diseases
  • Application of hyperoside in preparation of medicine for preventing and treating retina degenerative diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0039] In this example, the intervention effect of hyperoside on a mouse model of retinal photodamage was clarified through non-invasive retinal fundus tomography OCT technology, pathology and immunohistochemistry research methods. The research results show that hyperoside can effectively interfere with the death of photoreceptor cells and the occurrence of retinal degeneration, and play a significant protective effect on the structure of the retina.

[0040] 1. Method

[0041] 1. Drugs

[0042] Hyperin: purchased from Shanghai Yuanye Biotechnology Co., Ltd., 482-36-0, Lot#Y08N9X74602, purity ≥ 98%.

[0043] 2. Animal models

[0044] Six-week-old female Balb / c mice (Slack, Shanghai) were used for the experiment. Mice were randomly divided into normal control group, photodamage model control group and hyperin treatment group. Among them, the mice in the normal control group and the mice in the photodamage model control group received 100 μL of 0.5% sodium carboxymethylcellu...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to an application of hyperoside in preparation of a medicine for preventing and treating retina degenerative diseases, and the hyperoside is a compound with the following structural formula or pharmaceutically acceptable salt of the compound. Hyperoside has a remarkable inhibition effect on photoreceptor cell death induced by light injury, retina photoreceptor cell degenerative change and retina injury related immune inflammatory response, and can be used for remarkably treating and improving retina degenerative change; therefore, the compound can be used for preparing medicines for treating various retina degenerative diseases including age-related macular degeneration, retinitis pigmentosa, Stargardt disease, cone-rod cell dystrophy and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to the application of hyperin in the preparation of medicines for preventing and treating retinal degenerative diseases. Background technique [0002] Photoreceptor cells are retinal first-level sensory neurons that receive light stimulation in the retina and generate nerve impulses that are transmitted to the central nervous system. They play an extremely important role in the process of transmitting external information to the brain through the visual system. Photoreceptor cells include rod cells and cone cells, in which rod cells are responsible for the formation of scotopic vision, and cone cells are responsible for photopic and fine vision. A variety of environmental and genetic factors can lead to irreversible damage to photoreceptor cells, and its degenerative changes can directly lead to visual impairment or even blindness, including age-related macular degeneration, Stargard...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/7048A61P9/10A61P27/02
CPCA61K31/7048A61P9/10A61P27/02
Inventor 陈瑜张腾李岱瑾徐静杜霄烨崔金刚
Owner YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap